/*! tailwindcss v4.2.1 | MIT License | https://tailwindcss.com */
@layer theme{:root,:host{--font-sans:ui-sans-serif, system-ui, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji";--font-mono:ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace;--spacing:.25rem;--default-font-family:var(--font-sans);--default-mono-font-family:var(--font-mono)}}@layer base{*,:after,:before,::backdrop{box-sizing:border-box;border:0 solid;margin:0;padding:0}::file-selector-button{box-sizing:border-box;border:0 solid;margin:0;padding:0}html,:host{-webkit-text-size-adjust:100%;tab-size:4;line-height:1.5;font-family:var(--default-font-family,ui-sans-serif, system-ui, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji");font-feature-settings:var(--default-font-feature-settings,normal);font-variation-settings:var(--default-font-variation-settings,normal);-webkit-tap-highlight-color:transparent}hr{height:0;color:inherit;border-top-width:1px}abbr:where([title]){-webkit-text-decoration:underline dotted;text-decoration:underline dotted}h1,h2,h3,h4,h5,h6{font-size:inherit;font-weight:inherit}a{color:inherit;-webkit-text-decoration:inherit;-webkit-text-decoration:inherit;-webkit-text-decoration:inherit;-webkit-text-decoration:inherit;text-decoration:inherit}b,strong{font-weight:bolder}code,kbd,samp,pre{font-family:var(--default-mono-font-family,ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace);font-feature-settings:var(--default-mono-font-feature-settings,normal);font-variation-settings:var(--default-mono-font-variation-settings,normal);font-size:1em}small{font-size:80%}sub,sup{vertical-align:baseline;font-size:75%;line-height:0;position:relative}sub{bottom:-.25em}sup{top:-.5em}table{text-indent:0;border-color:inherit;border-collapse:collapse}:-moz-focusring{outline:auto}progress{vertical-align:baseline}summary{display:list-item}ol,ul,menu{list-style:none}img,svg,video,canvas,audio,iframe,embed,object{vertical-align:middle;display:block}img,video{max-width:100%;height:auto}button,input,select,optgroup,textarea{font:inherit;font-feature-settings:inherit;font-variation-settings:inherit;letter-spacing:inherit;color:inherit;opacity:1;background-color:#0000;border-radius:0}::file-selector-button{font:inherit;font-feature-settings:inherit;font-variation-settings:inherit;letter-spacing:inherit;color:inherit;opacity:1;background-color:#0000;border-radius:0}:where(select:is([multiple],[size])) optgroup{font-weight:bolder}:where(select:is([multiple],[size])) optgroup option{padding-inline-start:20px}::file-selector-button{margin-inline-end:4px}::placeholder{opacity:1}@supports (not ((-webkit-appearance:-apple-pay-button))) or (contain-intrinsic-size:1px){::placeholder{color:currentColor}@supports (color:color-mix(in lab, red, red)){::placeholder{color:color-mix(in oklab, currentcolor 50%, transparent)}}}textarea{resize:vertical}::-webkit-search-decoration{-webkit-appearance:none}::-webkit-date-and-time-value{min-height:1lh;text-align:inherit}::-webkit-datetime-edit{display:inline-flex}::-webkit-datetime-edit-fields-wrapper{padding:0}::-webkit-datetime-edit{padding-block:0}::-webkit-datetime-edit-year-field{padding-block:0}::-webkit-datetime-edit-month-field{padding-block:0}::-webkit-datetime-edit-day-field{padding-block:0}::-webkit-datetime-edit-hour-field{padding-block:0}::-webkit-datetime-edit-minute-field{padding-block:0}::-webkit-datetime-edit-second-field{padding-block:0}::-webkit-datetime-edit-millisecond-field{padding-block:0}::-webkit-datetime-edit-meridiem-field{padding-block:0}::-webkit-calendar-picker-indicator{line-height:1}:-moz-ui-invalid{box-shadow:none}button,input:where([type=button],[type=reset],[type=submit]){appearance:button}::file-selector-button{appearance:button}::-webkit-inner-spin-button{height:auto}::-webkit-outer-spin-button{height:auto}[hidden]:where(:not([hidden=until-found])){display:none!important}}@layer components;@layer utilities{.visible{visibility:visible}.relative{position:relative}.start{inset-inline-start:var(--spacing)}.block{display:block}.contents{display:contents}.table{display:table}}:root{--font-ui:"Hiragino Sans", "Hiragino Kaku Gothic ProN", "Yu Gothic", "Meiryo", "Noto Sans CJK JP", "Noto Sans JP", sans-serif;--ink:#123456;--ink-2:#233c55;--blue:#1e5791;--surface-blue:#edf4fa;--surface-soft:#f5f8fc;--green:var(--blue);--mint:var(--surface-blue);--cream:var(--surface-soft);--paper:#fff;--line:#cbd8e6;--muted:#4d6277;--accent:#2867a1;--accent-on-dark:#b5d8f5}*{box-sizing:border-box}html{scroll-behavior:smooth}@media (prefers-reduced-motion:reduce){html{scroll-behavior:auto}}body{background:var(--paper);color:var(--ink);font-family:var(--font-ui);margin:0;font-size:1rem;font-weight:600;line-height:1.8}a{color:inherit;text-decoration:none}.site-header{z-index:20;background:var(--paper);justify-content:space-between;align-items:center;min-height:82px;padding:12px clamp(24px,5vw,76px);display:flex;position:sticky;top:0}@supports (color:color-mix(in lab, red, red)){.site-header{background:color-mix(in srgb, var(--paper) 94%, transparent)}}.site-header{-webkit-backdrop-filter:blur(14px);backdrop-filter:blur(14px);border-bottom:1px solid #1234561a}.brand{align-items:center;gap:12px;display:flex}.brand-mark{background:var(--green);color:#fff;width:43px;height:43px;font:700 15px/1 var(--font-ui);border-radius:50% 48% 52% 45%;place-items:center;display:grid;transform:rotate(-5deg)}.brand>span:last-child{flex-direction:column;line-height:1.25;display:flex}.brand strong{letter-spacing:.04em;font-size:15px}.brand small{color:var(--muted);font:600 9px/1.2 var(--font-ui);letter-spacing:.08em;text-transform:uppercase;margin-top:4px}nav{align-items:center;gap:clamp(15px,2vw,30px);font-size:13px;font-weight:600;display:flex}nav a{border-bottom:1px solid #0000}nav a:hover,nav a:focus-visible{color:var(--green);border-color:currentColor}.nav-author{border-radius:99px;padding:8px 15px;border:1px solid var(--line)!important}.hero{grid-template-columns:minmax(0,1.1fr) minmax(360px,.75fr);align-items:center;gap:clamp(40px,6vw,92px);max-width:1440px;min-height:680px;margin:0 auto;padding:clamp(72px,9vw,130px) clamp(24px,8vw,120px) 105px;display:grid;position:relative;overflow:hidden}.hero:before{content:"";z-index:-1;background:0 0;border-radius:50%;width:580px;height:580px;position:absolute;top:-180px;right:-140px}.eyebrow{color:var(--green);font:700 11px/1.3 var(--font-ui);letter-spacing:.18em;margin:0 0 18px}.hero h1{font-family:var(--font-ui);letter-spacing:.01em;margin:0;font-size:clamp(44px,6vw,76px);font-weight:600;line-height:1.3}.hero h1 .hero-title-line{color:inherit;white-space:nowrap;display:block}.hero h1 .hero-title-mark{color:var(--green);white-space:nowrap;position:relative}.hero h1 .hero-title-mark:after{content:"";z-index:-1;background:#2867a14d;height:8px;position:absolute;bottom:5px;left:0;right:0}.hero-lead{margin:34px 0 8px;font-size:clamp(18px,2vw,23px);font-weight:700;line-height:1.9}.hero-note{max-width:680px;color:var(--muted);margin:0;font-size:15px}.hero-actions{flex-wrap:wrap;gap:12px;margin-top:35px;display:flex}.button{border-radius:4px;justify-content:center;align-items:center;gap:18px;min-height:52px;padding:0 23px;font-size:14px;font-weight:700;display:inline-flex}.button-primary{background:var(--ink);color:#fff;box-shadow:0 10px 30px #12345626}.button-primary:hover{background:var(--green);transform:translateY(-1px)}.button-secondary{border:1px solid var(--line);color:var(--ink);background:#fff}.button-secondary:hover{border-color:var(--green);color:var(--green);transform:translateY(-1px)}.button-quiet{border:1px solid var(--line);background:#ffffffa6}.button-quiet:hover{border-color:var(--green);color:var(--green)}.first-card{background:#fff;border:1px solid #1234561c;padding:clamp(28px,4vw,46px);position:relative;box-shadow:0 28px 80px #1234561a}.first-card:before{content:"";z-index:-1;border:1px solid #1e579124;position:absolute;inset:10px -10px -10px 10px}.card-kicker{border-bottom:1px solid var(--line);color:var(--green);letter-spacing:.12em;margin:0 0 21px;padding-bottom:16px;font-size:12px;font-weight:700}.first-card ol{margin:0;padding:0;list-style:none}.first-card li{grid-template-columns:38px 1fr;gap:14px;padding:16px 0;display:grid}.first-card li+li{border-top:1px dashed var(--line)}.first-card li>span{color:var(--accent);font:700 18px/1.2 var(--font-ui);padding-top:2px}.first-card strong{font-size:15px;display:block}.first-card li p{color:var(--muted);margin:5px 0 0;font-size:12px;line-height:1.7}.trust-strip{border-block:1px solid var(--line);grid-template-columns:repeat(3,1fr);max-width:1180px;margin:0 auto;display:grid}.trust-strip>div{justify-content:center;align-items:center;gap:14px;padding:23px 20px;display:flex}.trust-strip>div+div{border-left:1px solid var(--line)}.trust-strip span{background:var(--mint);width:25px;height:25px;color:var(--green);border-radius:50%;place-items:center;font-size:13px;display:grid}.trust-strip p{margin:0;line-height:1.3}.trust-strip strong{font-size:13px;display:block}.trust-strip small{color:var(--muted);font-size:10px}.section{max-width:1240px;margin:0 auto;padding:115px clamp(24px,5vw,74px)}.section-heading h2,.basics-copy h2,.placeholder-section h2{font-family:var(--font-ui);margin:0;font-size:clamp(32px,4.2vw,52px);font-weight:600;line-height:1.45}.section-heading>p:last-child{color:var(--muted);margin:16px 0 0}.audience-grid{grid-template-columns:repeat(3,1fr);gap:18px;display:grid}.audience-card{border:1px solid var(--line);background:#fff;flex-direction:column;min-height:330px;padding:31px;transition:transform .18s,box-shadow .18s;display:flex;position:relative}.audience-card:hover,.audience-card:focus-visible{transform:translateY(-5px);box-shadow:0 20px 55px #1234561a}.audience-card.featured{background:var(--ink);color:#fff;border-color:var(--ink)}.audience-no{color:var(--accent);font:700 24px/1 var(--font-ui);position:absolute;top:25px;right:27px}.audience-label{color:var(--green);letter-spacing:.11em;margin:0 0 24px;font-size:11px;font-weight:700}.featured .audience-label{color:#b5d8f5}.audience-card h3{max-width:270px;font-family:var(--font-ui);margin:0;font-size:23px;line-height:1.6}.audience-card>p:not(.audience-label){color:var(--muted);margin:20px 0 30px;font-size:13px}.featured>p:not(.audience-label){color:#d2dfec}.audience-card>strong{margin-top:auto;font-size:12px}.audience-card>strong span{color:var(--accent);margin-left:8px}.basics-section{grid-template-columns:.9fr 1.1fr;align-items:center;gap:clamp(50px,8vw,110px);display:grid}.basics-copy>p:not(.eyebrow){color:var(--muted);margin-top:28px}.definition{border-left:3px solid var(--green);background:var(--mint);align-items:center;gap:18px;margin-top:30px;padding:19px 22px;display:flex}.definition>span{font:700 23px/1 var(--font-ui);letter-spacing:.04em}.definition p{margin:0;line-height:1.5}.definition strong,.definition small{display:block}.definition small{color:var(--muted);margin-top:3px;font-size:10px}.duct-visual{background:var(--cream);min-height:360px;padding:35px;position:relative;overflow:hidden}.pancreas-shape{background:#e1b77d;border-radius:60% 30% 48% 45%/58% 50% 45% 55%;width:72%;height:36%;position:absolute;top:32%;left:13%;transform:rotate(-7deg);box-shadow:inset -22px -18px 35px #7a4a1f1f}.pancreas-shape:after{content:"";background:#ddb174;border-radius:60%;width:22%;height:70%;position:absolute;top:12%;right:-9%}.pancreas-shape>span{color:#452c16a6;font-size:11px;font-weight:700;position:absolute;top:18%;left:8%}.duct-line{background:#f8e8ca;border-radius:99px;height:7px;position:absolute;top:51%;left:16%;right:7%;transform:rotate(-1deg)}.cyst{color:#fff;background:#4f9787d6;border:5px solid #ffffffbd;border-radius:50%;position:absolute;box-shadow:0 8px 20px #1e57912e}.cyst.one{place-items:center;width:82px;height:82px;font-size:11px;display:grid;top:35%;left:50%}.cyst.two{width:46px;height:46px;top:51%;left:42%}.duct-visual>p{color:var(--muted);margin:0;font-size:12px;position:absolute;bottom:25px;left:34px}.risk-section{background:var(--ink);color:#fff;max-width:none;padding-inline:max(24px,50vw - 550px)}.section-heading.light{text-align:center;margin-inline:auto}.section-heading.light .eyebrow{color:#b5d8f5}.section-heading.light>p:last-child{color:#cbd8e6}.risk-layout{grid-template-columns:1fr 120px 1fr;align-items:center;gap:20px;max-width:1020px;margin:0 auto;display:grid}.risk-card{background:#ffffff0e;border:1px solid #ffffff2b;min-height:410px;padding:38px;position:relative}.risk-number{color:var(--accent);font:700 35px/1 var(--font-ui);position:absolute;top:25px;right:28px}.risk-type{color:#b5d8f5;letter-spacing:.08em;margin:0 0 12px;font-size:11px;font-weight:700}.risk-card h3{font-family:var(--font-ui);margin:0;font-size:30px}.risk-card>p:not(.risk-type){color:#cbd8e6;margin:22px 0;font-size:13px}.risk-card ul{flex-wrap:wrap;gap:7px;margin:30px 0 0;padding:0;list-style:none;display:flex}.risk-card li{color:#dce8f3;border:1px solid #ffffff2e;border-radius:99px;padding:6px 10px;font-size:10px}.risk-center{text-align:center}.risk-center>span{background:var(--accent);width:55px;height:55px;color:var(--ink);border-radius:50%;place-items:center;margin:0 auto 13px;font-size:30px;display:grid}.risk-center p{color:#cbd8e6;margin:0;font-size:11px;line-height:1.7}.risk-conclusion{max-width:1020px;color:var(--ink);text-align:center;background:#fff;margin:36px auto 0;padding:24px;font-size:16px}.risk-conclusion strong{color:var(--green)}.surveillance-section{background:var(--paper)}.watch-grid{border:1px solid var(--line);grid-template-columns:repeat(4,1fr);display:grid}.watch-grid article{background:#fff;min-height:270px;padding:31px 26px;position:relative}.watch-grid article>span{color:var(--accent);font:700 20px/1 var(--font-ui)}.watch-grid h3{font-family:var(--font-ui);margin:44px 0 12px;font-size:22px}.watch-grid p{color:var(--muted);margin:0;font-size:12px}.exam-row{grid-template-columns:repeat(3,1fr);gap:12px;margin-top:24px;display:grid}.exam-row>div{background:var(--cream);padding:25px}.exam-row strong{color:var(--green);font:700 15px/1.2 var(--font-ui)}.exam-row p{color:var(--muted);margin:10px 0 0;font-size:11px}.medical-note{border-left:2px solid var(--accent);color:var(--muted);margin:20px 0 0;padding-left:15px;font-size:11px}.specific-guides-section{max-width:1180px}.specific-guides-grid{grid-template-columns:repeat(3,1fr);gap:15px;display:grid}.specific-guides-grid>a{border:1px solid var(--line);background:#fff;flex-direction:column;min-height:330px;padding:31px;transition:transform .18s,box-shadow .18s;display:flex}.specific-guides-grid>a:hover,.specific-guides-grid>a:focus-visible{transform:translateY(-4px);box-shadow:0 18px 50px #1234561a}.specific-guides-grid>a>span{color:var(--green);font:700 11px/1.4 var(--font-ui);letter-spacing:.13em}.specific-guides-grid h3{font-family:var(--font-ui);margin:24px 0 15px;font-size:25px;line-height:1.55}.specific-guides-grid p{color:var(--muted);margin:0 0 25px;font-size:14px;line-height:1.8}.specific-guides-grid strong{color:var(--green);margin-top:auto;font-size:13px}.specific-guides-grid strong span{color:var(--accent);margin-left:7px}.latest-update-section{background:var(--mint);max-width:none}.latest-update-section>.section-heading{text-align:center;max-width:850px;margin-inline:auto}.latest-update-grid{grid-template-columns:1fr 1fr;gap:18px;max-width:1080px;margin:0 auto;display:grid}.latest-update-grid article{border-top:5px solid var(--green);background:#fff;flex-direction:column;min-height:390px;padding:clamp(28px,4vw,42px);display:flex;box-shadow:0 18px 50px #12345612}.update-label{color:var(--green);font:700 11px/1.4 var(--font-ui);letter-spacing:.12em;margin:0 0 20px}.latest-update-grid h3{font-family:var(--font-ui);margin:0;font-size:clamp(24px,3vw,31px);line-height:1.55}.latest-update-grid article>p:not(.update-label):not(.update-caution){color:var(--ink-2);margin:22px 0 0;font-size:16px;line-height:1.9}.update-caution{border-left:3px solid var(--accent);background:var(--cream);color:var(--muted);margin:20px 0 26px;padding:14px 16px;font-size:14px;line-height:1.8}.latest-update-grid a{border-bottom:1px solid var(--green);width:fit-content;color:var(--green);margin-top:auto;padding-bottom:3px;font-size:14px;font-weight:700}.latest-update-note{max-width:1080px;color:var(--muted);margin:22px auto 0;font-size:13px;line-height:1.8}.decision-section{background:var(--cream);padding:110px max(24px,50vw - 550px)}.decision-inner{grid-template-columns:1fr .9fr;align-items:center;gap:clamp(55px,8vw,110px);display:grid}.decision-copy h2,.book-copy h2,.author-copy h2,.faq-title h2,.contact-section h2{font-family:var(--font-ui);margin:0;font-size:clamp(32px,4vw,50px);font-weight:600;line-height:1.5}.decision-copy>p:not(.eyebrow){color:var(--muted);margin:25px 0}.decision-copy ul{grid-template-columns:1fr 1fr;gap:10px;margin:30px 0 0;padding:0;list-style:none;display:grid}.decision-copy li{background:#ffffffb3;padding:13px 15px 13px 35px;font-size:11px;position:relative}.decision-copy li:before{content:"✓";color:var(--green);font-weight:800;position:absolute;left:14px}.balance-card{background:#fff;border:1px solid #1234561a;grid-template-columns:1fr 48px 1fr;align-items:center;padding:40px 28px 27px;display:grid;box-shadow:0 25px 65px #12345617}.balance-side{flex-direction:column;justify-content:space-between;min-height:185px;padding:24px 19px;display:flex}.balance-side.disease{background:var(--ink);color:#fff}.balance-side.person{background:var(--mint)}.balance-side span{letter-spacing:.08em;font-size:10px}.balance-side strong{font-family:var(--font-ui);font-size:19px;line-height:1.6}.balance-mark{text-align:center;color:var(--accent);font:600 30px/1 var(--font-ui)}.balance-card>p{color:var(--muted);text-align:center;grid-column:1/-1;margin:22px 0 0;font-size:11px}.research-section{grid-template-columns:.72fr 1.28fr;align-items:start;gap:clamp(55px,9vw,120px);display:grid}.research-intro{position:sticky;top:125px}.research-intro h2,.works-heading h2{font-family:var(--font-ui);margin:0;font-size:clamp(36px,4.5vw,55px);font-weight:600}.research-intro>p:last-child{color:var(--muted);margin:22px 0 0}.timeline{margin:0;padding:0;list-style:none;position:relative}.timeline:before{content:"";background:var(--line);width:1px;position:absolute;top:9px;bottom:0;left:95px}.timeline li{grid-template-columns:72px 1fr;gap:44px;padding:0 0 42px;display:grid;position:relative}.timeline li:before{content:"";background:var(--accent);width:11px;height:11px;box-shadow:0 0 0 6px var(--paper);border-radius:50%;position:absolute;top:7px;left:90px}.timeline time{color:var(--green);font:700 10px/1.4 var(--font-ui);padding-top:1px}.timeline h3{font-family:var(--font-ui);margin:0 0 9px;font-size:22px}.timeline p{color:var(--muted);margin:0;font-size:12px}.works-section{background:var(--ink);color:#fff;grid-template-columns:minmax(260px,.55fr) 1fr;gap:clamp(50px,8vw,120px);padding:110px max(24px,50vw - 550px);display:grid}.works-heading .eyebrow{color:#b5d8f5}.works-heading h2{line-height:1.5}.works-list article{border-top:1px solid #ffffff2b;grid-template-columns:66px 1fr;gap:18px;padding:20px 0;display:grid}.works-list article:last-child{border-bottom:1px solid #ffffff2b}.works-list time{color:var(--accent);font:700 16px/1.5 var(--font-ui)}.works-list p{margin:0}.works-list strong{color:#b5d8f5;font:700 10px/1.4 var(--font-ui);letter-spacing:.1em;text-transform:uppercase;display:block}.works-list span{color:#dce8f3;font:600 13px/1.6 var(--font-ui);margin-top:7px;display:block}.works-note{color:#cbd8e6;grid-column:2;margin:4px 0 0;font-size:13px;line-height:1.8}.works-note a{color:#b5d8f5;width:fit-content;margin-top:8px;font-weight:700;display:block}.book-section{grid-template-columns:minmax(280px,.7fr) 1.3fr;align-items:center;gap:clamp(60px,10vw,130px);display:grid}.book-cover{background:var(--surface-blue);border:1px solid #cbd8e6;min-height:510px;padding:53px 39px;position:relative;overflow:hidden;box-shadow:24px 28px #123456,24px 29px 45px #12345626}.book-cover:after{content:"";border:16px solid #1e57912e;border-radius:60% 30% 55% 40%;width:175px;height:95px;position:absolute;bottom:65px;right:-42px;transform:rotate(-12deg)}.book-cover small{color:var(--green);font-size:10px;font-weight:700}.book-cover h3{font-family:var(--font-ui);margin:42px 0 15px;font-size:clamp(30px,3.5vw,45px);font-weight:600;line-height:1.45}.book-cover p{color:var(--green);font-family:var(--font-ui);margin:0;font-size:24px}.book-cover>span{font:600 9px/1 var(--font-ui);letter-spacing:.18em;position:absolute;bottom:34px;left:39px}.book-status{background:var(--mint);color:var(--green);border-radius:99px;margin:-5px 0 18px;padding:5px 11px;font-size:10px;font-weight:700;display:inline-block}.book-copy>p:not(.eyebrow){color:var(--muted);margin:27px 0}.book-copy dl{border-top:1px solid var(--line);margin:34px 0 0}.book-copy dl>div{border-bottom:1px solid var(--line);grid-template-columns:68px 1fr;padding:12px 0;font-size:12px;display:grid}.book-copy dt{color:var(--green);font-weight:700}.book-copy dd{margin:0}.author-section{background:var(--cream);padding:110px max(24px,50vw - 520px)}.author-inner{grid-template-columns:280px 1fr;align-items:center;gap:clamp(55px,8vw,100px);display:grid}.author-monogram{aspect-ratio:1;background:var(--ink);place-items:center;width:280px;display:grid;position:relative;overflow:hidden}.author-monogram:before,.author-monogram:after{content:"";border-radius:50%;position:absolute}.author-monogram:before{border:28px solid #b5d8f521;width:220px;height:220px;top:-60px;right:-75px}.author-monogram:after{background:#2867a129;width:130px;height:130px;bottom:-35px;left:-50px}.author-monogram span{color:#fff;font:700 62px/1 var(--font-ui);letter-spacing:-.08em;z-index:1}.author-copy h2 small{color:var(--muted);font:600 11px/1.4 var(--font-ui);letter-spacing:.05em;margin-left:15px;display:inline-block}.author-role{color:var(--green);margin:16px 0 25px;font-size:13px;font-weight:700}.author-copy>p:not(.eyebrow):not(.author-role){color:var(--muted)}.site-purpose{border-left:4px solid var(--accent);background:#ffffffc7;margin-top:35px;padding:clamp(25px,4vw,38px)}.site-purpose-label{color:var(--green);letter-spacing:.08em;margin:0 0 10px;font-size:11px;font-weight:700}.site-purpose h3{font-family:var(--font-ui);margin:0 0 19px;font-size:clamp(21px,2.5vw,27px);line-height:1.55}.site-purpose p:not(.site-purpose-label){color:var(--ink-2);margin:0;font-size:13px;line-height:1.95}.site-purpose p+p{margin-top:13px}.author-links{flex-wrap:wrap;gap:25px;margin-top:28px;display:flex}.author-links a{border-bottom:1px solid var(--green);color:var(--green);padding-bottom:3px;font-size:11px;font-weight:700}.faq-inner{grid-template-columns:.55fr 1fr;gap:clamp(50px,8vw,100px);display:grid}.faq-list{border-top:1px solid var(--line)}.faq-list details{border-bottom:1px solid var(--line)}.faq-list summary{cursor:pointer;font-family:var(--font-ui);padding:24px 45px 24px 0;font-size:17px;font-weight:700;list-style:none;position:relative}.faq-list summary::-webkit-details-marker{display:none}.faq-list summary:after{content:"+";color:var(--green);font:600 24px/1 var(--font-ui);position:absolute;right:8px}.faq-list details[open] summary:after{content:"−"}.faq-list details p{color:var(--muted);margin:-4px 35px 22px 0;font-size:12px}.contact-section{background:var(--green);color:#fff;text-align:center;padding:100px 24px}.contact-section .eyebrow{color:#dce8f3}.contact-section h2{max-width:800px;margin-inline:auto}.contact-section>p:not(.eyebrow){color:#dce8f3;margin:20px auto 28px}.contact-section .button-primary{color:var(--ink);background:#fff}.contact-section>small{color:#cbd8e6;margin-top:25px;font-size:9px;display:block}footer{color:#9eb3c8;background:#102d4a;justify-content:space-between;gap:25px;padding:28px max(24px,50vw - 600px);font-size:9px;display:flex}footer p{margin:0}:focus-visible{outline:3px solid var(--accent);outline-offset:4px}@media (width<=900px){.site-header{position:relative}nav a:not(.nav-author){display:none}.hero{grid-template-columns:1fr;min-height:0;padding-top:65px}.first-card{max-width:620px}.audience-grid,.specific-guides-grid,.latest-update-grid{grid-template-columns:1fr}.specific-guides-grid>a{min-height:0}.audience-card{min-height:280px}.basics-section{grid-template-columns:1fr}.duct-visual{min-height:330px}.risk-layout{grid-template-columns:1fr}.risk-center{justify-content:center;align-items:center;gap:12px;display:flex}.risk-center>span{margin:0}.risk-center p{text-align:left}.watch-grid{grid-template-columns:1fr 1fr}.watch-grid article+article{border-left:0}.watch-grid article:nth-child(2n){border-left:1px solid var(--line)}.watch-grid article:nth-child(n+3){border-top:1px solid var(--line)}.decision-inner,.research-section,.book-section,.author-inner,.faq-inner{grid-template-columns:1fr}.research-intro{position:static}.works-section{grid-template-columns:1fr}.works-note{grid-column:1}.book-cover{max-width:390px}.author-monogram{width:min(280px,100%)}}@media (width<=620px){.site-header{min-height:70px;padding-inline:18px}.brand-mark{width:37px;height:37px}.brand strong{font-size:13px}.brand small{display:none}.nav-author{padding:7px 10px;font-size:11px}.hero{padding-inline:22px;padding-bottom:75px}.desktop-break{display:none}.hero-lead{font-size:17px}.hero-actions{flex-direction:column}.button{width:100%}.first-card{padding:25px 22px}.trust-strip{grid-template-columns:1fr;padding:12px 20px}.trust-strip>div{justify-content:flex-start;padding:13px 5px}.trust-strip>div+div{border-left:0;border-top:1px solid var(--line)}.section{padding-block:82px}.audience-card{padding:26px 23px}.duct-visual{min-height:260px;padding:20px}.pancreas-shape{width:80%;left:9%}.cyst.one{width:65px;height:65px}.risk-card{min-height:auto;padding:31px 25px}.risk-conclusion{font-size:14px}.watch-grid,.exam-row{grid-template-columns:1fr}.watch-grid article{min-height:auto}.watch-grid article:nth-child(2n){border-left:0}.watch-grid article+article{border-top:1px solid var(--line)}.watch-grid h3{margin-top:25px}.decision-copy ul{grid-template-columns:1fr}.balance-card{padding-inline:15px}.balance-side{padding-inline:14px}.timeline:before{left:75px}.timeline li{grid-template-columns:58px 1fr;gap:34px}.timeline li:before{left:70px}.book-cover{min-height:440px;padding:38px 28px;box-shadow:14px 16px #123456}.book-cover>span{left:28px}.author-copy h2 small{margin:10px 0 0;display:block}.author-links{flex-direction:column;align-items:flex-start}footer{flex-direction:column}}body{background:#fff;font-size:17px;line-height:1.85}.site-header{min-height:72px;padding:10px clamp(20px,4vw,54px)}.brand strong{font-size:16px}.brand small{font-size:11px}nav{gap:clamp(14px,2vw,26px);font-size:15px}.hero{grid-template-columns:minmax(0,1.08fr) minmax(340px,.92fr);gap:clamp(36px,5vw,64px);max-width:1200px;min-height:0;padding:68px clamp(28px,5vw,64px) 72px}.hero:before{display:none}.eyebrow{letter-spacing:.12em;margin-bottom:14px;font-size:13px}.hero h1{font-size:clamp(42px,4.7vw,56px);line-height:1.28}.hero-lead{margin-top:26px;font-size:clamp(20px,2vw,24px);line-height:1.75}.hero-note{max-width:700px;font-size:17px}.hero-actions{margin-top:28px}.button{min-height:54px;padding-inline:24px;font-size:16px}.first-card{padding:30px 32px;box-shadow:0 12px 35px #12345614}.first-card:before{display:none}.card-kicker{margin-bottom:12px;padding-bottom:12px;font-size:14px}.first-card li{grid-template-columns:36px 1fr;padding:14px 0}.first-card li>span{font-size:18px}.first-card strong{font-size:17px}.first-card li p{margin-top:3px;font-size:15px;line-height:1.7}.trust-strip{max-width:1100px}.trust-strip>div{padding:18px 16px}.trust-strip strong{font-size:15px}.trust-strip small{font-size:13px}.section{max-width:1120px;padding:78px 32px}.section-heading{max-width:820px;margin-bottom:34px}.section-heading h2,.basics-copy h2{font-size:clamp(32px,3.7vw,44px);line-height:1.4}.section-heading>p:last-child{margin-top:12px;font-size:17px}.audience-grid{gap:16px}.audience-card{min-height:270px;padding:28px}.audience-label{letter-spacing:.06em;margin-bottom:17px;font-size:14px}.audience-card h3{max-width:none;font-size:22px;line-height:1.55}.audience-card>p:not(.audience-label){margin:14px 0 20px;font-size:16px}.audience-card>strong{font-size:15px}.basics-section{grid-template-columns:1fr 1fr;gap:48px}.basics-copy>p:not(.eyebrow){margin-top:20px;font-size:17px}.definition{margin-top:24px;padding:18px 20px}.definition>span{font-size:22px}.definition strong{font-size:17px}.definition small{font-size:13px}.basics-points{border-top:1px solid var(--line)}.basics-points article{border-bottom:1px solid var(--line);grid-template-columns:110px 1fr;gap:22px;padding:20px 0;display:grid}.basics-points p{color:var(--green);margin:0;font-size:15px;font-weight:700}.basics-points strong{font-size:17px;line-height:1.7}.risk-section{padding-block:78px}.risk-layout{grid-template-columns:1fr 70px 1fr;gap:15px;max-width:1000px}.risk-card{min-height:0;padding:30px}.risk-type{font-size:14px}.risk-card h3{font-size:28px}.risk-card>p:not(.risk-type){margin:16px 0;font-size:16px}.risk-card li{padding:6px 11px;font-size:13px}.risk-center p{font-size:13px}.risk-conclusion{margin-top:26px;padding:20px;font-size:18px}.watch-grid{grid-template-columns:1fr 1fr}.watch-grid article{min-height:0;padding:26px 28px}.watch-grid article+article{border-left:0}.watch-grid article:nth-child(2n){border-left:1px solid var(--line)}.watch-grid article:nth-child(n+3){border-top:1px solid var(--line)}.watch-grid article>span{font-size:17px}.watch-grid h3{margin:10px 0 8px;font-size:22px}.watch-grid p{font-size:16px}.exam-row{gap:14px;margin-top:18px}.exam-row>div{padding:22px}.exam-row strong{font-size:17px}.exam-row p{font-size:15px}.medical-note{margin-top:18px;font-size:14px}.decision-section{padding:78px max(32px,50vw - 528px)}.decision-inner{gap:48px}.decision-copy h2,.book-copy h2,.author-copy h2,.faq-title h2,.contact-section h2{font-size:clamp(32px,3.7vw,44px);line-height:1.4}.decision-copy>p:not(.eyebrow){margin:18px 0;font-size:17px}.decision-copy ul{margin-top:22px}.decision-copy li{padding:12px 14px 12px 38px;font-size:15px}.balance-card{box-shadow:none;padding:28px 22px 22px}.balance-side{min-height:150px;padding:20px 17px}.balance-side span{font-size:13px}.balance-side strong{font-size:19px}.balance-card>p{margin-top:17px;font-size:14px}.research-section{grid-template-columns:.8fr 1.2fr;gap:60px}.research-intro h2,.works-heading h2{font-size:clamp(34px,4vw,46px)}.research-intro>p:last-child{margin-top:16px;font-size:17px}.timeline li{padding-bottom:32px}.timeline time{font-size:13px}.timeline h3{margin-bottom:6px;font-size:22px}.timeline p{font-size:16px}.works-section{grid-template-columns:minmax(250px,.55fr) 1fr;gap:60px;padding:78px max(32px,50vw - 528px)}.works-list article{padding:17px 0}.works-list time{font-size:17px}.works-list strong{font-size:13px}.works-list span{margin-top:5px;font-size:16px;line-height:1.55}.works-note{font-size:14px}.book-section{max-width:960px;display:block}.book-copy{max-width:850px}.book-status{margin-bottom:14px;padding:6px 12px;font-size:14px}.book-copy>p:not(.eyebrow){margin:20px 0;font-size:17px}.book-copy dl{margin-top:24px}.book-copy dl>div{grid-template-columns:90px 1fr;padding:13px 0;font-size:16px}.author-section{padding:78px max(32px,50vw - 480px)}.author-inner{display:block}.author-copy{max-width:850px}.author-copy h2 small{font-size:14px}.author-role{margin:14px 0 18px;font-size:16px}.author-copy>p:not(.eyebrow):not(.author-role){font-size:17px}.author-links{margin-top:22px}.author-links a{font-size:15px}.faq-section{padding:78px max(32px,50vw - 528px)}.faq-inner{grid-template-columns:.5fr 1fr;gap:60px}.faq-list summary{padding:21px 45px 21px 0;font-size:19px;line-height:1.6}.faq-list details p{margin-bottom:21px;font-size:16px}.contact-section{padding:72px 24px}.contact-section>p:not(.eyebrow){margin:16px auto 24px;font-size:17px}.contact-section>small{margin-top:20px;font-size:13px}footer{padding-block:22px;font-size:13px}@media (width<=900px){.hero{grid-template-columns:1fr;padding-top:52px}.first-card{max-width:680px}.basics-section,.decision-inner,.research-section,.faq-inner,.works-section{grid-template-columns:1fr}.works-note{grid-column:1}.research-intro{position:static}}@media (width<=620px){body{font-size:16px}.site-header{min-height:66px;padding-inline:16px}.brand strong{font-size:14px}.hero{padding:44px 20px 54px}.hero h1{font-size:clamp(29px,9.5vw,40px)}.hero-lead{font-size:19px}.hero-note{font-size:16px}.section{padding:56px 20px}.latest-update-grid article{min-height:0}.section-heading{margin-bottom:26px}.audience-card{min-height:0}.basics-points article{grid-template-columns:1fr;gap:4px;padding:16px 0}.risk-section,.decision-section,.works-section,.author-section,.faq-section{padding:56px 20px}.risk-layout{grid-template-columns:1fr}.risk-center{padding:4px 0}.watch-grid,.exam-row{grid-template-columns:1fr}.watch-grid article:nth-child(2n){border-left:0}.watch-grid article+article{border-top:1px solid var(--line)}.decision-copy ul{grid-template-columns:1fr}.balance-card{grid-template-columns:1fr;gap:10px}.balance-mark{transform:rotate(45deg)}.works-section{gap:30px}.works-list article{grid-template-columns:55px 1fr;gap:12px}.book-copy dl>div{grid-template-columns:76px 1fr}.author-copy h2 small{font-size:13px}.faq-section{padding-bottom:62px}footer{font-size:12px}}.article-copy{border-top:1px solid var(--line);grid-template-columns:1fr 1fr;gap:42px;padding-top:30px;display:grid}.basics-explanation{grid-column:1/-1;margin-top:6px}.surveillance-explanation{margin-top:34px}.article-copy article{max-width:520px}.article-copy h3{font-family:var(--font-ui);margin:0 0 10px;font-size:23px;line-height:1.55}.article-copy p{color:var(--muted);margin:0;font-size:16px;line-height:1.9}.risk-explanation{border-top:1px solid #ffffff38;max-width:1000px;margin:28px auto 0;padding-top:26px}.risk-explanation h3{font-family:var(--font-ui);margin:0 0 12px;font-size:23px}.risk-explanation p{color:#cbd8e6;margin:8px 0 0;font-size:16px;line-height:1.9}@media (width<=760px){.article-copy{grid-template-columns:1fr;gap:24px}.article-copy article{max-width:none}}@media (width<=620px){.article-copy{padding-top:24px}.article-copy h3{font-size:21px}.article-copy p,.risk-explanation p{font-size:16px}}.article-page{background:#fff}.article-header .brand{flex:none}.article-hero{max-width:980px;margin:0 auto;padding:64px 32px 54px}.breadcrumb{color:var(--muted);align-items:center;gap:9px;margin-bottom:38px;font-size:13px;display:flex}.breadcrumb a{color:var(--green);border-bottom:1px solid}.breadcrumb span:last-child{text-overflow:ellipsis;white-space:nowrap;overflow:hidden}.article-hero h1{max-width:900px;font-family:var(--font-ui);margin:0;font-size:clamp(36px,5vw,58px);font-weight:600;line-height:1.42}.article-lead{max-width:820px;color:var(--ink-2);margin:25px 0 0;font-size:clamp(18px,2vw,21px);line-height:1.9}.article-author{border-left:4px solid var(--green);background:var(--mint);justify-content:space-between;gap:25px;margin-top:32px;padding:18px 20px;display:flex}.ipmn-illustration{margin:0}.ipmn-illustration-trigger{border:1px solid var(--line);cursor:zoom-in;background:#fff;border-radius:12px;text-decoration:none;display:block;overflow:hidden}.ipmn-illustration-trigger img{width:100%;height:auto;display:block}.ipmn-illustration-hint{color:var(--green);text-align:center;background:#edf4fa;padding:10px 16px;font-size:1rem;display:block}.ipmn-illustration-legend{gap:0;margin:18px 0;display:grid}.ipmn-illustration-legend>div{border-bottom:1px solid var(--line);grid-template-columns:minmax(110px,.3fr) minmax(0,1fr);gap:12px;padding:10px 0;display:grid}.ipmn-illustration-legend dt{color:var(--green);font-size:1rem;font-weight:700}.ipmn-illustration-legend dd{margin:0;font-size:1rem;line-height:1.75}.ipmn-illustration .ipmn-illustration-note{color:var(--muted);font-size:.875rem;line-height:1.8}.ipmn-image-dialog{box-sizing:border-box;width:min(1200px,100vw - 24px);max-width:calc(100vw - 24px);max-height:92dvh;color:var(--ink);background:#fff;border:0;border-radius:12px;padding:16px}.ipmn-image-dialog::backdrop{background:#000000a6}.ipmn-image-dialog-header{z-index:1;background:#fff;justify-content:space-between;align-items:center;gap:16px;padding:8px 0;display:flex;position:sticky;top:-16px}.ipmn-image-dialog-header button{border:1px solid var(--green);min-height:44px;color:var(--green);font:inherit;cursor:pointer;background:#fff;border-radius:8px;flex-shrink:0;padding:8px 18px}.ipmn-image-scroll{overscroll-behavior:contain;max-width:100%;overflow:auto}.ipmn-image-scroll img{width:max(900px,100%);max-width:none;height:auto;display:block}.ipmn-illustration .ipmn-image-dialog-help{margin:0 0 12px;font-size:.875rem}.ipmn-illustration-trigger:focus-visible,.ipmn-image-dialog button:focus-visible,.ipmn-image-scroll:focus-visible{outline:3px solid var(--green);outline-offset:3px}@media (width<=480px){.ipmn-illustration-legend>div{grid-template-columns:1fr;gap:3px}}.author-name-nowrap{white-space:nowrap;word-break:normal;overflow-wrap:normal;display:inline-block}.author-credit-link{flex-wrap:wrap;column-gap:1em;display:inline-flex}.article-author .author-credit-link>span{color:inherit}.article-author>*{min-width:0}.article-author p{margin:0;font-size:14px}.article-author p:first-child{flex-direction:column;display:flex}.article-author strong{font-size:16px}.article-author span,.article-author p:last-child{color:var(--muted)}.article-body{max-width:900px;margin:0 auto;padding:10px 32px 72px}.article-body>section{border-top:1px solid var(--line);padding:48px 0}.article-body h2,.related-section h2{font-family:var(--font-ui);margin:0 0 20px;font-size:clamp(28px,3.4vw,38px);font-weight:600;line-height:1.5}.article-body>section>p{color:var(--ink-2);margin:12px 0 0;font-size:17px;line-height:2}.key-box{border-left:4px solid var(--accent);background:var(--cream);margin-top:27px;padding:23px 25px}.key-box strong{font-size:18px;display:block}.key-box p{color:var(--ink-2);margin:7px 0 0;font-size:16px}.article-check-grid{grid-template-columns:1fr 1fr;gap:13px;display:grid}.article-check-grid article{border:1px solid var(--line);padding:24px}.article-check-grid span{color:var(--accent);font:700 17px/1 var(--font-ui)}.article-check-grid h3{font-family:var(--font-ui);margin:12px 0 7px;font-size:21px}.article-check-grid p{color:var(--muted);margin:0;font-size:15px;line-height:1.8}.article-check-grid article>a{color:var(--accent);text-underline-offset:4px;margin-top:14px;font-size:14px;font-weight:700;text-decoration:underline;display:inline-block}.plain-check-list{gap:11px;margin:24px 0 0;padding:0;list-style:none;display:grid}.plain-check-list li{border:1px solid var(--line);background:#fff;padding:20px 22px 20px 58px;position:relative}.plain-check-list li:before{content:"✓";background:var(--mint);width:25px;height:25px;color:var(--green);border-radius:50%;place-items:center;font-weight:800;display:grid;position:absolute;top:19px;left:20px}.plain-check-list strong{color:var(--ink);font-size:17px;line-height:1.65;display:block}.plain-check-list span{color:var(--muted);margin-top:5px;font-size:15px;line-height:1.8;display:block}.article-list{border-top:1px solid var(--line);margin:0;padding:0;list-style:none}.article-list li{border-bottom:1px solid var(--line);padding:15px 15px 15px 38px;font-size:16px;position:relative}.article-list li:before{content:"✓";color:var(--green);font-weight:800;position:absolute;left:13px}.two-risk-article{grid-template-columns:1fr 1fr;gap:16px;display:grid}.two-risk-article article{background:var(--ink);color:#fff;padding:28px}.two-risk-article article>span{color:#b5d8f5;letter-spacing:.1em;font-size:12px;font-weight:700}.two-risk-article h3{font-family:var(--font-ui);margin:12px 0;font-size:25px}.two-risk-article p{color:#cbd8e6;margin:0;font-size:16px}.two-risk-article ul{flex-wrap:wrap;gap:7px;margin:20px 0 0;padding:0;list-style:none;display:flex}.two-risk-article li{border:1px solid #ffffff40;border-radius:99px;padding:5px 9px;font-size:13px}.article-source-note{border-left:3px solid var(--green);padding-left:16px;color:var(--muted)!important;font-size:14px!important}.answer-box{border:1px solid #1e579133;border-top:5px solid var(--green);background:var(--mint);margin-top:24px;padding:clamp(24px,4vw,34px)}.answer-box strong{font-family:var(--font-ui);font-size:21px;line-height:1.75;display:block}.answer-box p{color:var(--ink-2);margin:11px 0 0;font-size:16px;line-height:1.9}.interval-table{border:1px solid var(--line);margin-top:25px;overflow-x:auto}.interval-table table{border-collapse:collapse;background:#fff;width:100%;min-width:620px}.interval-table th,.interval-table td{border-bottom:1px solid var(--line);text-align:left;vertical-align:top;padding:18px 19px;font-size:15px;line-height:1.7}.interval-table thead th{background:var(--ink);color:#fff;font-size:14px}.interval-table tbody th{background:var(--cream);width:25%;color:var(--green)}.interval-table tbody tr:last-child th,.interval-table tbody tr:last-child td{border-bottom:0}.question-list{counter-reset:questions;gap:12px;margin:0;padding:0;list-style:none;display:grid}.question-list li{border:1px solid var(--line);counter-increment:questions;padding:22px 23px 22px 66px;position:relative}.question-list li:before{content:counter(questions);background:var(--green);color:#fff;width:29px;height:29px;font:700 14px/1 var(--font-ui);border-radius:50%;place-items:center;display:grid;position:absolute;top:19px;left:22px}.question-list strong{font-size:17px;line-height:1.7;display:block}.question-list span{color:var(--muted);margin-top:4px;font-size:15px;line-height:1.75;display:block}.exam-detail-grid{border:1px solid var(--line);background:var(--line);grid-template-columns:repeat(3,1fr);gap:1px;margin-top:22px;display:grid}.exam-detail-grid>div{background:#fff;padding:24px}.exam-detail-grid strong{color:var(--green);font-size:16px;display:block}.exam-detail-grid p{color:var(--ink-2);margin:9px 0 0;font-size:15px;line-height:1.85}.evidence-section{margin-top:16px}.evidence-section>p:not(.eyebrow){max-width:760px}.reference-list{border-top:1px solid var(--line);margin:24px 0 0;padding:0;list-style:none}.reference-list li{border-bottom:1px solid var(--line);gap:5px;padding:18px 8px;display:grid}.reference-list a{width:fit-content;color:var(--green);border-bottom:1px solid;font-size:15px;font-weight:700;line-height:1.65}.reference-list span{color:var(--muted);font-size:13px;line-height:1.65}.exam-article-grid{grid-template-columns:repeat(3,1fr);gap:12px;display:grid}.exam-article-grid article{background:var(--cream);padding:24px}.exam-article-grid strong{color:var(--green);font-size:18px}.exam-article-grid p{color:var(--muted);margin:9px 0 0;font-size:15px;line-height:1.8}.article-disclaimer{border:1px solid var(--line);background:#fafafa;max-width:836px;margin:0 auto 72px;padding:22px 25px}.article-disclaimer strong{font-size:15px}.article-disclaimer p{color:var(--muted);margin:6px 0 0;font-size:14px;line-height:1.8}.related-section{background:var(--cream);padding:66px max(32px,50vw - 450px)}.related-grid{grid-template-columns:1fr 1fr;gap:15px;display:grid}.related-grid a{border:1px solid var(--line);background:#fff;padding:26px;display:block}.related-grid strong{font-family:var(--font-ui);font-size:22px}.related-grid p{color:var(--muted);margin:8px 0 18px;font-size:15px}.related-grid span{color:var(--green);font-size:14px;font-weight:700}@media (width<=900px){.article-header nav a:not(.nav-author){display:none}}@media (width<=680px){.article-hero{padding:42px 20px 40px}.breadcrumb{margin-bottom:28px}.article-hero h1{font-size:34px}.article-author{flex-direction:column;align-items:flex-start;gap:8px}.article-body{padding:0 20px 54px}.article-body>section{padding:38px 0}.article-guide-cta{grid-template-columns:1fr;gap:20px;margin:0 20px 54px;padding:24px 22px}.article-guide-cta h2{font-size:22px}.article-guide-cta>a{white-space:normal;text-align:center;width:100%}.article-check-grid,.two-risk-article,.exam-article-grid,.exam-detail-grid,.related-grid{grid-template-columns:1fr}.answer-box{padding:22px 19px}.answer-box strong{font-size:19px}.question-list li{padding:20px 18px 20px 58px}.question-list li:before{left:17px}.article-disclaimer{margin:0 20px 54px}.related-section{padding:50px 20px}}.publications-page{background:#fff}.publications-hero{max-width:1040px;margin:0 auto;padding:64px 32px 58px}.publications-hero h1{font-family:var(--font-ui);margin:0;font-size:clamp(40px,5vw,62px);font-weight:600;line-height:1.4}.publications-lead{max-width:800px;color:var(--ink-2);margin:23px 0 0;font-size:19px;line-height:1.95}.publication-scope-line{border-left:3px solid var(--accent);width:fit-content;max-width:800px;color:var(--ink-2);background:#ffffffad;align-items:baseline;gap:12px;margin:18px 0 0;padding:12px 16px;font-size:14px;line-height:1.7;display:flex}.publication-scope-line strong{color:var(--green);flex:none;font-size:13px}.publication-summary{border:1px solid var(--line);background:var(--line);grid-template-columns:repeat(3,1fr);gap:1px;margin-top:38px;display:grid}.publication-summary>div{background:var(--cream);padding:21px 23px}.publication-summary strong{color:var(--green);font-size:16px;display:block}.publication-summary span{color:var(--muted);margin-top:5px;font-size:14px;line-height:1.6;display:block}.publication-jump{flex-wrap:wrap;gap:10px;margin-top:20px;display:flex}.publication-jump a{border:1px solid var(--line);color:var(--green);background:#fff;border-radius:4px;padding:11px 16px;font-size:14px;font-weight:700;text-decoration:none}.publication-jump a:hover{border-color:var(--green);background:var(--mint)}.publications-body{max-width:960px;margin:0 auto;padding:10px 32px 82px}.publications-body>section{border-top:1px solid var(--line);padding:62px 0}.publications-body h2{font-family:var(--font-ui);margin:0;font-size:clamp(30px,4vw,42px);font-weight:600;line-height:1.5}.section-intro{max-width:780px;color:var(--ink-2);margin:15px 0 30px;font-size:16px;line-height:1.9}.publication-topic-block{margin-top:46px}.publication-topic-block>h3,.original-publication-heading{color:var(--ink);font-family:var(--font-ui);margin:0;font-size:clamp(23px,3vw,30px);font-weight:600;line-height:1.55}.publication-topic-block>p{max-width:780px;color:var(--muted);margin:9px 0 21px;font-size:15px;line-height:1.8}.original-publication-heading{margin-top:35px}.translated-publication-list{grid-template-columns:repeat(2,minmax(0,1fr));gap:16px;margin:0;padding:0;list-style:none;display:grid}.translated-publication-list>li{border:1px solid var(--line);background:#fff;border-radius:6px;padding:23px 24px 21px}.translated-publication-meta{flex-wrap:wrap;align-items:center;gap:8px 12px;margin-bottom:10px;display:flex}.translated-publication-meta time{color:var(--green);font:700 14px/1.5 var(--font-ui)}.translated-publication-meta span{color:var(--muted);font-size:13px;line-height:1.5}.translated-publication-list h4{color:var(--ink);font-family:var(--font-ui);margin:0;font-size:19px;font-weight:600;line-height:1.65}.translated-publication-list>li>p{color:var(--ink-2);margin:11px 0 0;font-size:15px;line-height:1.85}.translated-publication-list .publication-original-title{border-top:1px solid var(--line);color:var(--muted);font:600 13px/1.65 var(--font-ui);margin:15px 0 0;padding-top:12px}.translation-note{border-left:4px solid var(--accent);background:var(--cream);margin-top:42px;padding:22px 25px}.translation-note strong{font-size:16px}.translation-note p{color:var(--ink-2);margin:6px 0 0;font-size:15px;line-height:1.8}.jp-publication-list{border-top:1px solid var(--line);margin:0;padding:0;list-style:none}.jp-publication-list li{border-bottom:1px solid var(--line);grid-template-columns:70px 1fr;gap:22px;padding:21px 8px;display:grid}.jp-publication-list time{color:var(--green);font:700 15px/1.5 var(--font-ui);padding-top:3px}.jp-publication-list h3{color:var(--ink);font-family:var(--font-ui);margin:0;font-size:19px;line-height:1.65}.jp-publication-list p{color:var(--muted);margin:4px 0 0;font-size:14px;line-height:1.6}.publication-note{border-left:4px solid var(--green);background:var(--mint);margin-top:18px;padding:22px 25px}.publication-note strong{font-size:16px}.publication-note p{color:var(--ink-2);margin:6px 0 0;font-size:15px;line-height:1.8}.publications-actions{flex-wrap:wrap;gap:12px;margin-top:34px;display:flex}@media (width<=680px){.publications-hero{padding:42px 20px 44px}.publications-hero h1{font-size:38px}.publications-lead{font-size:17px}.publication-scope-line{flex-direction:column;align-items:flex-start;gap:2px}.publication-summary{grid-template-columns:1fr}.publication-jump{flex-direction:column;align-items:stretch}.publication-jump a{text-align:center}.publications-body{padding:0 20px 58px}.publications-body>section{padding:46px 0}.publication-topic-block{margin-top:38px}.translated-publication-list{grid-template-columns:1fr}.translated-publication-list>li{padding:20px 18px 18px}.translated-publication-list h4{font-size:18px}.jp-publication-list li{grid-template-columns:54px 1fr;gap:14px;padding:18px 0}.jp-publication-list h3{font-size:18px}}.verified-publications-body{max-width:960px;margin:0 auto;padding:4px 32px 88px}.pubmed-translation-note{margin:0 0 46px}.verified-year-section{border-top:1px solid var(--line);padding:38px 0 16px}.verified-year-heading{justify-content:space-between;align-items:baseline;gap:20px;margin-bottom:15px;display:flex}.verified-year-heading h2{color:var(--green);font:700 clamp(28px, 4vw, 38px)/1.2 var(--font-ui);margin:0}.verified-year-heading span{color:var(--muted);font-size:14px}.verified-publication-list{border-top:1px solid var(--line);margin:0;padding:0;list-style:none}.verified-publication-list>li{border-bottom:1px solid var(--line)}.verified-publication-list>li[id]{scroll-margin-top:96px}.verified-publication-list>li[id]:target{box-shadow:inset 4px 0 0 var(--green);background:#f3f7fb}.verified-publication-list article{padding:24px 8px 23px}.verified-publication-meta{flex-wrap:wrap;gap:7px 14px;margin-bottom:8px;display:flex}.verified-publication-meta span{color:var(--muted);font:600 13px/1.5 var(--font-ui)}.verified-publication-meta span:first-child{color:var(--green);font-weight:700}.verified-publication-list h3{max-width:820px;color:var(--ink);font-family:var(--font-ui);margin:0;font-size:20px;font-weight:600;line-height:1.65}.verified-publication-list details{margin-top:10px}.verified-publication-list summary{width:fit-content;color:var(--green);cursor:pointer;font-size:13px;font-weight:700}.verified-original-title{max-width:850px;color:var(--ink-2);font:600 15px/1.7 var(--font-ui);margin:9px 0 0}.verified-citation{max-width:850px;color:var(--muted);font:600 13px/1.65 var(--font-ui);margin:6px 0 0}.verified-publication-links{flex-wrap:wrap;gap:9px 18px;margin-top:14px;display:flex}.verified-publication-links a{color:var(--green);font-size:13px;font-weight:700}@media (width<=680px){.verified-publications-body{padding:0 20px 60px}.pubmed-translation-note{margin-bottom:34px}.verified-year-section{padding-top:32px}.verified-publication-list article{padding:21px 0 20px}.verified-publication-list h3{font-size:18px}}.hero-definition{border-left:4px solid var(--accent);background:var(--cream);max-width:700px;margin:18px 0 14px;padding:17px 19px}.hero-definition strong{color:var(--green);margin-bottom:4px;font-size:16px;display:block}.hero-definition p{color:var(--ink-2);margin:0;font-size:15px;line-height:1.8}.hero-definition b{color:var(--ink)}.audience-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.related-grid{grid-template-columns:repeat(3,minmax(0,1fr))}.term-definition-box{border:1px solid var(--line);background:var(--cream);grid-template-columns:130px 1fr;align-items:center;gap:24px;margin:22px 0 26px;padding:25px 27px;display:grid}.term-abbreviation{color:var(--green);font:700 35px/1 var(--font-ui);letter-spacing:.04em;margin:0}.term-definition-box strong{font-family:var(--font-ui);font-size:23px;display:block}.term-definition-box div p{color:var(--muted);font:600 14px/1.6 var(--font-ui);margin:5px 0 0}.ipmn-type-grid{grid-template-columns:repeat(3,1fr);gap:14px;margin-top:24px;display:grid}.ipmn-type-grid article{border:1px solid var(--line);background:#fff;padding:23px 22px}.ipmn-type-grid span{color:var(--green);font:700 12px/1.4 var(--font-ui);letter-spacing:.08em}.ipmn-type-grid h3{font-family:var(--font-ui);margin:9px 0 8px;font-size:21px}.ipmn-type-grid p{color:var(--muted);margin:0;font-size:15px;line-height:1.8}.profile-page{background:#fff}.profile-hero{max-width:980px;margin:0 auto;padding:64px 32px 58px}.profile-hero h1{font-family:var(--font-ui);margin:0;font-size:clamp(40px,5vw,60px);font-weight:600;line-height:1.35}.profile-hero h1 small{color:var(--muted);font:600 15px/1.5 var(--font-ui);letter-spacing:.04em;margin-top:10px;display:block}.profile-role{color:var(--green);margin:22px 0 0;font-size:17px;font-weight:700;line-height:1.7}.profile-summary{border-left:5px solid var(--accent);background:var(--cream);max-width:850px;margin-top:30px;padding:27px 30px 29px}.profile-summary>strong{color:var(--green);font-family:var(--font-ui);font-size:clamp(25px,3.2vw,34px);font-weight:600;line-height:1.45;display:block}.profile-summary>p{color:var(--ink-2);margin:12px 0 0;font-size:17px;line-height:1.9}.profile-section-nav{flex-wrap:wrap;gap:9px;margin-top:24px;display:flex}.profile-section-nav a{border:1px solid var(--line);min-height:42px;color:var(--green);background:#fff;align-items:center;padding:9px 14px;font-size:13px;font-weight:700;display:inline-flex}.profile-section-nav a:after{content:"↓";color:var(--accent);margin-left:8px;font-size:12px}.profile-section-nav a:hover,.profile-section-nav a:focus-visible{border-color:var(--green);background:#f3f7fb}.profile-body{max-width:960px;margin:0 auto;padding:0 32px 82px}.profile-body>section{border-top:1px solid var(--line);padding:62px 0}.profile-body h2{font-family:var(--font-ui);margin:0;font-size:clamp(30px,4vw,42px);font-weight:600;line-height:1.5}.profile-body>section>p:not(.eyebrow){max-width:820px;color:var(--ink-2);margin:18px 0 0;font-size:17px;line-height:1.95}.profile-biography-grid{grid-template-columns:minmax(0,1.45fr) minmax(250px,.8fr);align-items:start;gap:30px;margin-top:28px;display:grid}.profile-biography-grid dl{border-top:1px solid var(--line);margin:0}.profile-biography-grid dl>div{border-bottom:1px solid var(--line);grid-template-columns:105px 1fr;gap:18px;padding:17px 0;display:grid}.profile-biography-grid dt{color:var(--green);font-size:14px;font-weight:700}.profile-biography-grid dd{color:var(--ink-2);margin:0;font-size:16px;line-height:1.75}.profile-biography-grid aside{border:1px solid var(--line);background:var(--paper);padding:24px 25px}.profile-biography-grid aside strong{color:var(--green);font-family:var(--font-ui);font-size:21px;display:block}.profile-biography-grid aside p{color:var(--ink-2);margin:10px 0 15px;font-size:15px;line-height:1.85}.profile-biography-grid aside a{color:var(--green);text-underline-offset:4px;font-size:13px;font-weight:700;text-decoration:underline}.profile-clinical-scope,#research-focus{scroll-margin-top:92px}.profile-clinical-grid,.profile-focus-grid{grid-template-columns:repeat(2,1fr);gap:14px;margin-top:28px;display:grid}.profile-clinical-grid>a,.profile-focus-grid>a{border:1px solid var(--line);background:var(--paper);flex-direction:column;min-height:255px;padding:25px 24px;transition:transform .18s,border-color .18s,box-shadow .18s;display:flex}.profile-clinical-grid>a{background:#f5f8fc;min-height:245px}.profile-clinical-grid>a:hover,.profile-clinical-grid>a:focus-visible,.profile-focus-grid>a:hover,.profile-focus-grid>a:focus-visible{border-color:var(--green);transform:translateY(-3px);box-shadow:0 14px 36px #12345617}.profile-clinical-grid span,.profile-focus-grid span{color:var(--accent);font:700 17px/1 var(--font-ui)}.profile-clinical-grid h3,.profile-focus-grid h3{font-family:var(--font-ui);margin:9px 0 8px;font-size:21px;line-height:1.55}.profile-clinical-grid p,.profile-focus-grid p{color:var(--muted);margin:0;font-size:15px;line-height:1.8}.profile-clinical-grid strong,.profile-focus-grid strong{color:var(--green);align-items:center;gap:7px;margin-top:auto;padding-top:18px;font-size:13px;display:inline-flex}.profile-clinical-grid strong b,.profile-focus-grid strong b{font-size:16px;font-weight:600}.profile-chemotherapy-feature{grid-template-columns:1.08fr .92fr;align-items:start;gap:42px;scroll-margin-top:92px;display:grid}.profile-chemotherapy-feature>div>p:not(.eyebrow){color:var(--ink-2);margin:17px 0 0;font-size:16px;line-height:1.95}.profile-chemotherapy-feature .button{margin-top:24px}.profile-chemotherapy-feature nav{border-top:1px solid var(--line)}.profile-chemotherapy-feature nav a{border-bottom:1px solid var(--line);flex-direction:column;gap:5px;padding:17px 4px;display:flex}.profile-chemotherapy-feature nav strong{color:var(--ink);font-family:var(--font-ui);font-size:17px;line-height:1.55}.profile-chemotherapy-feature nav span{color:var(--green);font-size:12px;font-weight:700}.profile-research-history{scroll-margin-top:92px}.profile-research-history .timeline{margin-top:34px;padding:4px 0 0}.profile-research-history .timeline p{font-size:15px;line-height:1.8}.profile-research-history .timeline time{font-size:12px}.profile-history-links{flex-wrap:wrap;gap:12px;margin:4px 0 0 116px;display:flex}.profile-history-links a{border:1px solid var(--green);color:var(--green);padding:10px 14px;font-size:13px;font-weight:700}.profile-selected-publications{scroll-margin-top:92px}.profile-selected-intro{max-width:780px}.profile-work-chapters{gap:42px;margin-top:34px;display:grid}.profile-work-chapter{scroll-margin-top:92px}.profile-work-chapter>header{border-bottom:3px solid var(--green);grid-template-columns:52px 1fr;align-items:start;gap:18px;padding:0 0 18px;display:grid}.profile-work-chapter>header>span{background:var(--green);color:#fff;width:46px;height:46px;font:700 14px/1 var(--font-ui);letter-spacing:.08em;border-radius:50%;place-items:center;display:grid}.profile-work-chapter>header h3{color:var(--ink);font-family:var(--font-ui);margin:0 0 6px;font-size:24px;line-height:1.45}.profile-work-chapter>header p{color:var(--muted);margin:0;font-size:15px;line-height:1.8}.profile-selected-works{border-top:1px solid var(--line);margin:30px 0 0;padding:0;list-style:none}.profile-selected-works li{border-bottom:1px solid var(--line)}.profile-selected-works li>a{grid-template-columns:78px 1fr;gap:26px;padding:24px 18px;transition:background .16s;display:grid}.profile-selected-works li>a:hover,.profile-selected-works li>a:focus-visible{background:var(--paper)}.profile-selected-works time{color:var(--accent);font:700 17px/1.5 var(--font-ui);padding-top:3px}.profile-selected-works div>span{color:var(--green);letter-spacing:.06em;text-transform:uppercase;font-size:12px;font-weight:800}.profile-selected-works h3,.profile-selected-works h4{color:var(--ink);font-family:var(--font-ui);margin:7px 0 5px;font-size:20px;line-height:1.55}.profile-selected-works p{color:var(--muted);font:600 14px/1.7 var(--font-ui);margin:0}.profile-selected-works .profile-work-significance{color:var(--ink);margin:8px 0 7px;font-family:inherit;font-size:14px;line-height:1.75}.profile-selected-works .profile-work-original{color:var(--muted)}.profile-selected-works strong{color:var(--green);margin-top:10px;font-size:12px;display:block}.profile-selected-actions{flex-wrap:wrap;gap:12px;margin-top:24px;display:flex}.profile-selected-actions a{border:1px solid var(--green);color:var(--green);padding:10px 14px;font-size:13px;font-weight:700}.profile-site-purpose{scroll-margin-top:92px}.profile-purpose-card{border-left:5px solid var(--accent);background:var(--cream);margin-top:28px;padding:clamp(25px,4vw,38px)}.profile-purpose-card h3{font-family:var(--font-ui);margin:0 0 20px;font-size:clamp(23px,3vw,30px);line-height:1.55}.profile-purpose-card p{color:var(--ink-2);margin:0;font-size:16px;line-height:1.95}.profile-purpose-card p+p{margin-top:15px}.profile-actions{flex-wrap:wrap;gap:12px;margin-top:28px;display:flex}.translated-publication-list>li[id]{scroll-margin-top:96px}.translated-publication-list>li[id]:target{border-color:var(--green);background:#f3f7fb;box-shadow:0 0 0 3px #1e57911f}@media (width<=900px){.hero,.audience-grid,.ipmn-type-grid,.related-grid{grid-template-columns:1fr}}@media (width<=680px){.hero-definition{padding:15px 16px}.hero-definition strong{font-size:15px}.hero-definition p{font-size:14px}.term-definition-box{grid-template-columns:1fr;gap:10px;padding:21px 19px}.term-abbreviation{font-size:30px}.term-definition-box strong{font-size:20px}.profile-hero{padding:42px 20px 46px}.profile-hero h1{font-size:38px}.profile-summary{padding:22px 20px 23px}.profile-summary>strong{font-size:25px}.profile-summary>p{font-size:16px}.profile-body{padding:0 20px 58px}.profile-body>section{padding:46px 0}.profile-biography-grid{grid-template-columns:1fr;gap:22px}.profile-biography-grid dl>div{grid-template-columns:88px 1fr;gap:12px}.profile-section-nav{grid-template-columns:repeat(2,minmax(0,1fr));display:grid}.profile-section-nav a{justify-content:space-between;padding:10px 12px}.profile-clinical-grid,.profile-focus-grid{grid-template-columns:1fr}.profile-history-links{flex-direction:column;align-items:stretch;margin-left:0}.profile-history-links a{text-align:center}.profile-selected-works li>a{grid-template-columns:1fr;gap:5px;padding:20px 4px}.profile-work-chapters{gap:34px}.profile-work-chapter>header{grid-template-columns:42px 1fr;gap:13px}.profile-work-chapter>header>span{width:38px;height:38px;font-size:12px}.profile-work-chapter>header h3{font-size:21px}.profile-selected-actions{flex-direction:column;align-items:stretch}.profile-selected-actions a{text-align:center}.profile-purpose-card{padding:24px 20px}.profile-purpose-card p{font-size:15px}.profile-actions{flex-direction:column;align-items:stretch}}.quick-guide{border-bottom:1px solid var(--line);background:#edf4fa}.quick-guide-inner{grid-template-columns:minmax(210px,.72fr) minmax(0,2.6fr);align-items:center;gap:26px;max-width:1200px;margin:0 auto;padding:22px 32px 24px;display:grid}.quick-guide-heading p{color:var(--green);font:700 12px/1.4 var(--font-ui);letter-spacing:.12em;margin:0 0 5px}.quick-guide-heading h2{color:var(--ink);font-family:var(--font-ui);margin:0;font-size:21px;font-weight:600;line-height:1.5}.quick-guide-links{grid-template-columns:repeat(3,minmax(0,1fr));gap:8px;display:grid}.quick-guide-links a{min-height:72px;color:var(--ink);background:#fff;border:1px solid #cbd8e6;border-radius:5px;flex-direction:column;justify-content:center;padding:13px 35px 12px 15px;text-decoration:none;transition:border-color .18s,box-shadow .18s,transform .18s;display:flex;position:relative}.quick-guide-links a:hover,.quick-guide-links a:focus-visible{border-color:var(--green);transform:translateY(-1px);box-shadow:0 5px 16px #12345617}.quick-guide-links a>span:first-child{color:var(--muted);font-size:12px;font-weight:700;line-height:1.45}.quick-guide-links strong{margin-top:3px;font-size:15px;line-height:1.5}.quick-guide-links a>span:last-child{color:var(--green);font-size:15px;position:absolute;bottom:14px;right:14px}@media (width<=900px){.quick-guide-inner{grid-template-columns:1fr;gap:15px;padding:20px 24px 22px}.quick-guide-heading{align-items:baseline;gap:12px;display:flex}.quick-guide-heading p{flex:none}.quick-guide-heading h2{font-size:19px}}@media (width<=620px){.quick-guide-inner{padding:17px 16px 19px}.quick-guide-heading{padding:0 2px;display:block}.quick-guide-heading h2{font-size:18px}.quick-guide-links{grid-template-columns:repeat(2,minmax(0,1fr));gap:7px}.quick-guide-links a{min-height:82px;padding:12px 29px 11px 12px}.quick-guide-links a>span:first-child{font-size:11px}.quick-guide-links strong{font-size:14px}.quick-guide-links a>span:last-child{bottom:11px;right:10px}}.nav-guide{color:var(--green);border-radius:99px;padding:8px 13px;border:1px solid var(--green)!important}.nav-urgent{color:#fff;background:#8f3d35;border-radius:99px;padding:8px 13px}.nav-urgent:hover,.nav-urgent:focus-visible{color:#fff;background:#713029;border-color:#0000}.integrated-portal-bar{background:var(--ink);color:#fff;border-bottom:1px solid #cbd8e6}.integrated-portal-bar>div{justify-content:space-between;align-items:center;gap:26px;max-width:1200px;margin:0 auto;padding:16px 32px;display:flex}.integrated-portal-bar p{margin:0;line-height:1.55}.integrated-portal-bar strong{margin-right:15px;font-size:15px}.integrated-portal-bar span{color:#cbd8e6;font-size:13px}.integrated-portal-bar a{color:#c0ddf5;border-bottom:1px solid #b5d8f5;flex:none;padding-bottom:2px;font-size:14px;font-weight:700}.article-portal-bar{z-index:3;position:relative}.article-guide-cta{background:#edf4fa;border:1px solid #cbd8e6;grid-template-columns:minmax(0,1fr) auto;align-items:center;gap:34px;max-width:900px;margin:0 auto 72px;padding:30px 32px;display:grid}.article-guide-cta p{color:var(--green);letter-spacing:.08em;margin:0 0 8px;font-size:12px;font-weight:700}.article-guide-cta h2{font-family:var(--font-ui);margin:0;font-size:24px;line-height:1.5}.article-guide-cta div>span{color:var(--muted);margin-top:9px;font-size:14px;line-height:1.75;display:block}.article-guide-cta>a{background:var(--ink);color:#fff;white-space:nowrap;border-radius:4px;justify-content:center;align-items:center;gap:12px;min-height:52px;padding:0 20px;font-size:14px;font-weight:700;display:inline-flex}.article-guide-cta>a:hover{background:var(--green)}.home-guide-bridge{border-bottom:1px solid var(--line);grid-template-columns:minmax(280px,.85fr) minmax(0,1.15fr);gap:clamp(42px,7vw,90px);max-width:1240px;margin:0 auto;padding:88px clamp(24px,5vw,74px);display:grid}.home-guide-copy h2{font-family:var(--font-ui);margin:0;font-size:clamp(31px,4vw,48px);font-weight:600;line-height:1.5}.home-guide-copy>p:not(.eyebrow){color:var(--muted);margin:21px 0 28px;font-size:16px;line-height:1.95}.home-guide-links{grid-template-columns:1fr 1fr;gap:10px;display:grid}.home-guide-links a{border:1px solid var(--line);background:#fff;flex-direction:column;justify-content:center;min-height:126px;padding:22px 42px 22px 23px;display:flex;position:relative}.home-guide-links a:hover{border-color:var(--green);box-shadow:0 10px 32px #12345614}.home-guide-links a.urgent{background:#fff5f2;border-color:#e6c7c0}.home-guide-links a>span:first-child{color:var(--green);letter-spacing:.08em;font-size:12px;font-weight:700}.home-guide-links strong{font-family:var(--font-ui);margin-top:5px;font-size:18px;line-height:1.55}.home-guide-links a>span:last-child{color:var(--accent);position:absolute;bottom:21px;right:20px}.guide-home,.guide-article-page{background:#fff}.guide-site-header{background:#fffffff2}.guide-brand-mark{background:var(--ink);letter-spacing:.04em;border-radius:8px;font-size:13px;transform:none}.guide-brand small{text-transform:none;letter-spacing:.05em}.waiting-guide-hero{background:var(--surface-blue);border-bottom:1px solid var(--line);grid-template-columns:minmax(0,1.15fr) minmax(310px,.65fr);gap:34px 46px;max-width:1360px;margin:0 auto;padding:58px clamp(28px,7vw,104px) 70px;display:grid}.waiting-guide-heading{max-width:720px}.waiting-guide-label{background:var(--mint);color:var(--green);border-radius:99px;margin:0 0 20px;padding:8px 13px;font-size:13px;font-weight:700;display:inline-flex}.waiting-guide-heading h1{font-family:var(--font-ui);margin:0;font-size:clamp(42px,5vw,62px);font-weight:600;line-height:1.35}.waiting-guide-heading>p:last-child{max-width:650px;color:var(--ink-2);margin:22px 0 0;font-size:clamp(17px,1.6vw,20px);line-height:1.9}.waiting-urgent{background:#fff7f5;border:1px solid #e2c3bd;border-left:6px solid #8f3d35;align-self:end;padding:27px 29px}.waiting-urgent>span{color:#8f3d35;letter-spacing:.08em;font-size:12px;font-weight:700}.waiting-urgent>strong{color:#713029;font-family:var(--font-ui);margin-top:8px;font-size:24px;display:block}.waiting-urgent p{color:var(--ink-2);margin:10px 0 17px;font-size:14px;line-height:1.75}.waiting-urgent a{color:#713029;text-underline-offset:4px;font-size:13px;font-weight:700;text-decoration:underline}.waiting-topic-grid{grid-column:1/-1;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px;display:grid}.waiting-topic-grid>a{border:1px solid var(--line);background:#fff;flex-direction:column;min-height:174px;padding:22px 47px 21px 23px;transition:transform .18s,border-color .18s,box-shadow .18s;display:flex;position:relative}.waiting-topic-grid>a:hover,.waiting-topic-grid>a:focus-visible{border-color:var(--green);transform:translateY(-3px);box-shadow:0 14px 38px #12345617}.waiting-topic-no{color:var(--accent);font:700 18px/1 var(--font-ui);position:absolute;top:20px;right:21px}.waiting-topic-grid small{color:var(--green);font-size:11px;font-weight:700}.waiting-topic-grid strong{font-family:var(--font-ui);margin-top:13px;font-size:22px;line-height:1.4}.waiting-topic-grid p{color:var(--muted);margin:8px 0 0;font-size:13px;line-height:1.7}.waiting-topic-grid b{color:var(--green);font-weight:600;position:absolute;bottom:18px;right:20px}.guide-hero{background:var(--surface-blue);grid-template-columns:minmax(0,1.18fr) minmax(330px,.72fr);align-items:center;gap:clamp(42px,7vw,92px);max-width:1360px;min-height:590px;margin:0 auto;padding:82px clamp(28px,7vw,104px) 90px;display:grid}.guide-hero h1,.guide-hero h2{font-family:var(--font-ui);margin:0;font-size:clamp(42px,4.9vw,60px);font-weight:600;line-height:1.34}.guide-title-line{white-space:nowrap;display:block}.guide-hero h1 .guide-title-accent,.guide-hero h2 .guide-title-accent{color:var(--green)}.guide-intro-hero{background:var(--surface-blue)}.guide-hero-lead{max-width:770px;color:var(--ink-2);margin:28px 0 0;font-size:clamp(17px,1.7vw,21px);line-height:1.95}.guide-hero-actions{flex-wrap:wrap;gap:12px;margin-top:30px;display:flex}.guide-principle-card{background:#fff;border:1px solid #12345624;padding:32px;box-shadow:0 25px 70px #1234561a}.guide-principle-card ol{margin:0;padding:0;list-style:none}.guide-principle-card li{border-top:1px solid var(--line);grid-template-columns:36px 1fr;gap:13px;padding:17px 0;display:grid}.guide-principle-card li>span{color:var(--accent);font:700 18px/1.3 var(--font-ui)}.guide-principle-card strong{font-size:16px}.guide-principle-card li p{color:var(--muted);margin:5px 0 0;font-size:13px;line-height:1.7}.guide-route-section,.guide-distinction-section{max-width:1180px;margin:0 auto;padding:92px 32px}.guide-section-heading{max-width:760px;margin-bottom:38px}.guide-section-heading h2,.guide-evidence-policy h2,.guide-ipmn-bridge h2{font-family:var(--font-ui);margin:0;font-size:clamp(31px,4vw,48px);font-weight:600;line-height:1.5}.guide-section-heading>p:last-child{color:var(--muted);margin:13px 0 0;font-size:16px}.guide-route-grid{grid-template-columns:repeat(3,1fr);gap:13px;display:grid}.guide-route-grid>a{border:1px solid var(--line);background:#fff;flex-direction:column;min-height:295px;padding:27px;transition:transform .18s,box-shadow .18s,border-color .18s;display:flex}.guide-route-grid>a:hover,.guide-route-grid>a:focus-visible{border-color:var(--green);transform:translateY(-4px);box-shadow:0 17px 45px #12345617}.guide-route-grid>a>span{color:var(--accent);font:700 22px/1 var(--font-ui);align-self:flex-end}.guide-route-grid small{color:var(--green);letter-spacing:.08em;font-size:12px;font-weight:700}.guide-route-grid h3{font-family:var(--font-ui);margin:19px 0 11px;font-size:23px;line-height:1.55}.guide-route-grid p{color:var(--muted);margin:0 0 22px;font-size:14px;line-height:1.8}.guide-route-grid strong{color:var(--green);margin-top:auto;font-size:13px}.guide-journey-section{background:var(--ink);color:#fff;padding:92px max(32px,50vw - 558px)}.guide-section-heading.light .eyebrow{color:#b5d8f5}.guide-section-heading.light>p:last-child{color:#cbd8e6}.care-journey{border:1px solid #ffffff29;grid-template-columns:repeat(5,1fr);margin:0;padding:0;list-style:none;display:grid}.care-journey li{min-height:230px;padding:25px 21px}.care-journey li+li{border-left:1px solid #ffffff29}.care-journey span{color:var(--accent);font:700 18px/1 var(--font-ui)}.care-journey strong{font-family:var(--font-ui);margin-top:42px;font-size:19px;line-height:1.55;display:block}.care-journey p{color:#cbd8e6;margin:11px 0 0;font-size:13px;line-height:1.7}.distinction-grid{grid-template-columns:1fr 1fr;gap:12px;display:grid}.distinction-grid article{border:1px solid var(--line);background:var(--paper);padding:29px}.distinction-grid span{color:var(--green);letter-spacing:.1em;font-size:12px;font-weight:700}.distinction-grid h3{font-family:var(--font-ui);margin:10px 0 8px;font-size:22px}.distinction-grid p{color:var(--muted);margin:0;font-size:15px;line-height:1.85}.guide-evidence-policy{background:var(--cream);grid-template-columns:.72fr 1.28fr;gap:clamp(55px,8vw,105px);padding:88px max(32px,50vw - 540px);display:grid}.evidence-policy-copy>p:first-child{color:var(--ink-2);margin:0;font-size:17px;line-height:1.95}.evidence-policy-copy dl{border-top:1px solid var(--line);margin:27px 0 0}.evidence-policy-copy dl>div{border-bottom:1px solid var(--line);grid-template-columns:160px 1fr;gap:20px;padding:17px 0;display:grid}.evidence-policy-copy dt{color:var(--green);font-weight:700}.evidence-policy-copy dd{color:var(--muted);margin:0}.guide-caution{border-left:4px solid var(--accent);color:var(--ink-2);background:#fff;margin:25px 0 0;padding:17px 19px;font-size:14px;line-height:1.85}.guide-ipmn-bridge{grid-template-columns:1fr 1fr;align-items:center;gap:65px;max-width:1120px;margin:0 auto;padding:90px 32px;display:grid}.guide-ipmn-bridge>div:first-child>p:last-child{color:var(--muted);font-size:16px}.guide-ipmn-links{border-top:1px solid var(--line)}.guide-ipmn-links a{border-bottom:1px solid var(--line);color:var(--green);justify-content:space-between;gap:20px;padding:19px 6px;font-weight:700;display:flex}.guide-article-hero{max-width:980px;margin:0 auto;padding:58px 32px 48px}.guide-article-hero h1{font-family:var(--font-ui);margin:0;font-size:clamp(36px,4.8vw,56px);font-weight:600;line-height:1.42}.guide-article-lead{max-width:850px;color:var(--ink-2);margin:22px 0 0;font-size:clamp(18px,2vw,21px);line-height:1.95}.guide-answer-strip{flex-wrap:wrap;align-items:center;gap:9px;margin-top:26px;display:flex}.guide-answer-strip strong{color:var(--green);margin-right:5px;font-size:13px}.guide-answer-strip span{background:var(--mint);color:var(--ink-2);border-radius:99px;padding:7px 11px;font-size:12px;font-weight:700}.guide-author-line{margin-top:27px}.field-path-navigation{border:1px solid var(--line);background:#fff;max-width:1080px;margin:0 auto 34px;padding:22px 24px 24px}.field-path-heading{justify-content:space-between;align-items:baseline;gap:10px 22px;margin-bottom:15px;display:flex}.field-path-heading strong{color:var(--ink);font-family:var(--font-ui);font-size:18px}.field-path-heading span{color:var(--muted);font-size:13px}.field-path-navigation ol{grid-template-columns:repeat(7,minmax(0,1fr));gap:7px;margin:0;padding:0;list-style:none;display:grid}.field-path-guide ol{grid-template-columns:repeat(6,minmax(0,1fr))}.field-path-navigation li>a,.field-path-navigation li>span{border:1px solid var(--line);min-height:70px;color:var(--green);flex-direction:column;justify-content:space-between;padding:11px 10px;font-size:12px;font-weight:700;line-height:1.45;display:flex}.field-path-navigation li>a{background:var(--paper);transition:border-color .16s,background .16s}.field-path-navigation li>a:hover,.field-path-navigation li>a:focus-visible{border-color:var(--green);background:var(--mint)}.field-path-navigation li small{color:var(--accent);font:700 13px/1 var(--font-ui)}.field-path-navigation li>a>span{align-self:flex-end;font-size:17px;line-height:1}.field-path-navigation .is-current{border-color:var(--green);background:var(--green);color:#fff}.field-path-navigation .is-current small{color:#fff;opacity:.78}.field-path-navigation .is-current em{color:#dce8f3;font-size:10px;font-style:normal}.context-link-cards{background:#f3f7fb;margin:42px 0;padding:31px;border:0!important}.context-link-heading h2{margin-bottom:8px!important;font-size:clamp(25px,3vw,32px)!important}.context-link-heading>p:last-child{color:var(--muted);margin:0;font-size:14px;line-height:1.7}.context-link-cards nav{grid-template-columns:repeat(3,minmax(0,1fr));gap:9px;margin-top:22px;display:grid}.context-link-cards nav a{border:1px solid var(--line);background:#fff;flex-direction:column;min-height:176px;padding:20px;display:flex}.context-link-cards nav a:hover,.context-link-cards nav a:focus-visible{border-color:var(--green)}.context-link-cards nav strong{color:var(--ink);font-family:var(--font-ui);font-size:18px;line-height:1.55}.context-link-cards nav span{color:var(--muted);margin-top:7px;font-size:13px;line-height:1.7}.context-link-cards nav em{color:var(--green);margin-top:auto;padding-top:15px;font-size:12px;font-style:normal;font-weight:700}.article-body>section[id]{scroll-margin-top:92px}.guide-article-body{max-width:900px;margin:0 auto;padding:5px 32px 68px}.guide-article-body>section{border-top:1px solid var(--line);padding:46px 0}.guide-article-body h2{font-family:var(--font-ui);margin:0 0 19px;font-size:clamp(28px,3.4vw,38px);font-weight:600;line-height:1.5}.guide-article-body>section>p{color:var(--ink-2);margin:12px 0 0;font-size:17px;line-height:2}.guide-disclaimer{max-width:836px}.guide-related .related-grid{grid-template-columns:repeat(3,minmax(0,1fr))}.page-terms{background:#f3f7fb;grid-template-columns:.78fr 1.22fr;gap:48px;margin:0 0 18px;display:grid;border:0!important;padding:34px!important}.page-terms-heading h2{margin-bottom:12px;font-size:clamp(25px,3vw,33px)}.page-terms-heading>p:not(.eyebrow){color:var(--muted);margin:0;font-size:14px;line-height:1.8}.page-terms-heading>a{color:var(--green);margin-top:18px;font-size:13px;font-weight:700;display:inline-block}.page-terms dl{border-top:1px solid var(--line);margin:0}.page-terms dl>div{border-bottom:1px solid var(--line);padding:13px 0}.page-terms dt{color:var(--ink);font-weight:700;line-height:1.6}.page-terms dt a{color:inherit;justify-content:space-between;align-items:center;gap:12px;display:flex}.page-terms dt a span{color:var(--green);white-space:nowrap;font-size:11px}.page-terms dd{color:var(--muted);margin:4px 0 0;font-size:14px;line-height:1.75}.article-glossary-link{border-left:4px solid var(--green);background:var(--mint);grid-template-columns:auto 1fr auto;align-items:center;gap:12px 20px;margin-top:22px;padding:17px 19px;display:grid}.article-glossary-link strong{color:var(--ink);font-size:14px}.article-glossary-link span{color:var(--ink-2);font-size:13px;line-height:1.65}.article-glossary-link a{color:var(--green);white-space:nowrap;font-size:13px;font-weight:700}.article-term-primer{background:#f3f7fb;grid-template-columns:.72fr 1.28fr;gap:44px;max-width:960px;margin:0 auto 16px;padding:30px 32px;display:grid}.article-term-primer h2{font-family:var(--font-ui);margin:0;font-size:clamp(25px,3vw,32px)}.article-term-primer>div>p:last-child{color:var(--muted);font-size:14px;line-height:1.75}.article-term-primer dl{border-top:1px solid var(--line);margin:0}.article-term-primer dl>div{border-bottom:1px solid var(--line);padding:11px 0}.article-term-primer dt{font-weight:700}.article-term-primer dt a{color:inherit;justify-content:space-between;align-items:center;gap:12px;display:flex}.article-term-primer dt a span{color:var(--green);white-space:nowrap;font-size:11px}.article-term-primer dd{color:var(--muted);margin:3px 0 0;font-size:13px;line-height:1.7}.waiting-glossary-link{color:var(--green);margin-top:19px;font-size:14px;font-weight:700;display:inline-block}.guide-glossary-bridge{border-top:1px solid var(--line);justify-content:space-between;align-items:center;gap:42px;max-width:1116px;margin:0 auto;padding:68px 32px;display:flex}.guide-glossary-bridge>div{max-width:690px}.guide-glossary-bridge h2{font-family:var(--font-ui);margin:0;font-size:clamp(28px,3.4vw,40px);line-height:1.5}.guide-glossary-bridge p{color:var(--muted);line-height:1.9}.glossary-page{background:var(--paper);min-height:100vh}.glossary-hero{background:var(--surface-blue);padding:74px max(32px,50vw - 530px) 62px}.glossary-hero h1{font-family:var(--font-ui);margin:0;font-size:clamp(39px,5.6vw,66px);font-weight:600;line-height:1.36}.glossary-hero>p:not(.eyebrow){max-width:760px;color:var(--ink-2);margin:22px 0 0;font-size:18px;line-height:1.95}.glossary-index{flex-wrap:wrap;gap:10px;margin-top:30px;display:flex}.glossary-index a{border:1px solid var(--green);color:var(--green);background:#fff;border-radius:99px;padding:10px 16px;font-size:13px;font-weight:700}.glossary-content{max-width:920px;margin:0 auto;padding:22px 32px 86px}.glossary-section{border-bottom:1px solid var(--line);padding:58px 0;scroll-margin-top:78px}.glossary-section h2{font-family:var(--font-ui);margin:0 0 24px;font-size:clamp(30px,3.8vw,42px);font-weight:600}.glossary-list{margin:0}.glossary-list>div{border-top:1px solid var(--line);grid-template-columns:245px 1fr;gap:28px;padding:20px 0;display:grid}.glossary-list dt{color:var(--ink);font-size:17px;font-weight:700;line-height:1.65}.glossary-list dd{color:var(--ink-2);margin:0;font-size:16px;line-height:1.9}.glossary-detail-link{width:fit-content;color:var(--green);margin-top:8px;font-size:13px;font-weight:700;line-height:1.6;display:block}.glossary-note{border-left:5px solid var(--accent);background:#fff;margin-top:58px;padding:30px}.glossary-note>strong{font-family:var(--font-ui);font-size:23px}.glossary-note>p{color:var(--muted);line-height:1.9}.glossary-note>div{flex-wrap:wrap;gap:10px;margin-top:22px;display:flex}.guide-topic-list{grid-template-columns:1fr 1fr;gap:12px;display:grid}.guide-topic-list>a,.guide-topic-list>article{border:1px solid var(--line);background:#fff;flex-direction:column;min-height:260px;padding:25px;display:flex}.guide-topic-list>a:hover{border-color:var(--green);box-shadow:0 12px 35px #12345614}.guide-topic-list small{color:var(--accent);font:700 16px/1 var(--font-ui)}.guide-topic-list h3{font-family:var(--font-ui);margin:17px 0 9px;font-size:22px}.guide-topic-list p{color:var(--muted);margin:0 0 18px;font-size:15px;line-height:1.8}.guide-topic-list strong{color:var(--green);margin-top:auto;font-size:13px}.decision-ladder{border:1px solid var(--line);grid-template-columns:repeat(3,1fr);margin-top:26px;display:grid}.decision-ladder>div{background:#fff;min-height:210px;padding:24px;position:relative}.decision-ladder>div+div{border-left:1px solid var(--line)}.decision-ladder span{color:var(--green);letter-spacing:.08em;font-size:11px;font-weight:700}.decision-ladder strong{font-family:var(--font-ui);margin-top:28px;font-size:20px;display:block}.decision-ladder p{color:var(--muted);margin:9px 0 0;font-size:14px;line-height:1.8}.urgent-inline-section{background:#fff5f2;margin:8px 0;border:0!important;padding:35px!important}.urgent-inline-section h2{color:#713029}.urgent-inline-section .button{margin-top:23px}.test-comparison,.treatment-grid{grid-template-columns:1fr 1fr;gap:12px;display:grid}.test-comparison article,.treatment-grid article{border:1px solid var(--line);background:#fff;padding:25px}.test-comparison span,.treatment-grid span{color:var(--green);letter-spacing:.1em;font-size:11px;font-weight:700}.test-comparison h3,.treatment-grid h3{font-family:var(--font-ui);margin:10px 0 9px;font-size:22px}.test-comparison p,.treatment-grid p{color:var(--muted);margin:8px 0 0;font-size:1rem;line-height:1.8}.treatment-grid a,.key-box a{color:var(--green);font-weight:700}.article-official-link{border-bottom:1px solid var(--green);color:var(--green);margin-top:22px;padding-bottom:4px;font-size:14px;font-weight:700;display:inline-flex}.chemotherapy-fact-box{border:1px solid var(--line);background:var(--line);grid-template-columns:repeat(3,1fr);gap:1px;margin-top:27px;display:grid}.chemotherapy-fact-box>div{background:var(--paper);min-height:160px;padding:23px}.chemotherapy-fact-box span{color:var(--accent);letter-spacing:.08em;font-size:11px;font-weight:800;display:block}.chemotherapy-fact-box strong{color:var(--ink);font-family:var(--font-ui);margin-top:20px;font-size:18px;line-height:1.65;display:block}.chemotherapy-research-links{gap:8px;margin-top:27px;display:grid}.chemotherapy-research-links a{border:1px solid var(--line);background:var(--paper);grid-template-columns:1fr auto;align-items:center;gap:18px;padding:17px 19px;display:grid}.chemotherapy-research-links strong{color:var(--ink);font-size:15px;line-height:1.65}.chemotherapy-research-links span{color:var(--green);white-space:nowrap;font-size:12px;font-weight:700}.test-comparison p strong{color:var(--ink-2)}.urgent-card-list{gap:12px;display:grid}.urgent-card-list article{background:#fff8f6;border:1px solid #e4c6c0;padding:25px 25px 25px 75px;position:relative}.urgent-card-list span{color:#fff;width:32px;height:32px;font:700 12px/1 var(--font-ui);background:#8f3d35;border-radius:50%;place-items:center;display:grid;position:absolute;top:26px;left:24px}.urgent-card-list h3{color:#713029;font-family:var(--font-ui);margin:0 0 7px;font-size:21px}.urgent-card-list p{color:var(--ink-2);margin:0;font-size:15px;line-height:1.8}.treatment-path{border:1px solid var(--line);background:var(--line);grid-template-columns:repeat(4,1fr);gap:1px;margin-top:24px;display:grid}.treatment-path>div{background:#fff;min-height:240px;padding:23px}.treatment-path span{background:var(--green);color:#fff;border-radius:50%;place-items:center;width:32px;height:32px;font-weight:700;display:grid}.treatment-path h3{font-family:var(--font-ui);margin:28px 0 8px;font-size:19px}.treatment-path p{color:var(--muted);margin:0;font-size:14px;line-height:1.8}@media (width<=1040px){.guide-site-header nav a:not(.nav-urgent){display:none}.waiting-guide-hero{grid-template-columns:1fr}.waiting-urgent{max-width:720px}.waiting-topic-grid{grid-template-columns:1fr 1fr}.guide-hero{background:var(--surface-blue);grid-template-columns:1fr}.guide-principle-card{max-width:720px}.care-journey{grid-template-columns:1fr 1fr}.care-journey li+li{border-left:0}.care-journey li:nth-child(2n){border-left:1px solid #ffffff29}.care-journey li:nth-child(n+3){border-top:1px solid #ffffff29}.guide-related .related-grid{grid-template-columns:1fr}.treatment-path{grid-template-columns:1fr 1fr}.field-path-navigation ol{grid-template-columns:repeat(4,minmax(0,1fr))}.field-path-guide ol{grid-template-columns:repeat(3,minmax(0,1fr))}}@media (width<=820px){.integrated-portal-bar>div{flex-direction:column;align-items:flex-start;gap:9px;padding:15px 24px}.integrated-portal-bar strong,.integrated-portal-bar span{display:block}.integrated-portal-bar span{margin-top:3px}.home-guide-bridge,.guide-evidence-policy,.guide-ipmn-bridge{grid-template-columns:1fr}.guide-route-grid{grid-template-columns:1fr 1fr}.decision-ladder{grid-template-columns:1fr}.decision-ladder>div+div{border-top:1px solid var(--line);border-left:0}.page-terms{grid-template-columns:1fr;gap:26px}.article-glossary-link{grid-template-columns:1fr}.article-term-primer{grid-template-columns:1fr;gap:22px}.guide-glossary-bridge{flex-direction:column;align-items:flex-start}.context-link-cards nav{grid-template-columns:1fr}.context-link-cards nav a{min-height:136px}}@media (width<=620px){.site-header{min-height:70px;padding:9px 16px}.site-header nav .nav-guide{display:none}.guide-site-header nav .nav-urgent{padding:7px 10px;font-size:11px;display:inline-flex}.brand strong{font-size:13px}.brand small{font-size:8px}.brand-mark{width:39px;height:39px}.integrated-portal-bar>div{padding:13px 16px}.integrated-portal-bar strong{font-size:14px}.integrated-portal-bar span,.integrated-portal-bar a{font-size:12px}.home-guide-bridge{padding:56px 20px}.home-guide-links{grid-template-columns:1fr}.home-guide-links a{min-height:105px}.waiting-guide-hero{gap:25px;padding:38px 20px 48px}.waiting-guide-label{margin-bottom:15px;font-size:12px}.waiting-guide-heading h1{font-size:38px}.waiting-guide-heading>p:last-child{font-size:16px}.waiting-urgent{padding:22px 20px}.waiting-urgent>strong{font-size:21px}.waiting-topic-grid{grid-template-columns:1fr;gap:9px}.waiting-topic-grid>a{min-height:145px}.guide-hero{min-height:auto;padding:55px 20px 62px}.guide-hero h1,.guide-hero h2{font-size:36px}.guide-title-line{white-space:normal}.guide-hero-lead{font-size:17px}.guide-principle-card{padding:24px 20px}.guide-route-section,.guide-distinction-section{padding:58px 20px}.guide-route-grid,.distinction-grid,.guide-topic-list,.test-comparison,.treatment-grid{grid-template-columns:1fr}.guide-route-grid>a{min-height:245px}.guide-journey-section{padding:58px 20px}.care-journey{grid-template-columns:1fr}.care-journey li{min-height:auto}.care-journey li+li,.care-journey li:nth-child(2n){border-top:1px solid #ffffff29;border-left:0}.care-journey strong{margin-top:24px}.guide-evidence-policy,.guide-ipmn-bridge{gap:36px;padding:58px 20px}.evidence-policy-copy dl>div{grid-template-columns:1fr;gap:4px}.guide-article-hero{padding:42px 20px 38px}.guide-article-hero h1{font-size:34px}.guide-article-lead{font-size:17px}.guide-answer-strip{flex-direction:column;align-items:flex-start}.field-path-navigation{margin:0 20px 28px;padding:20px 16px}.field-path-heading{flex-direction:column;align-items:flex-start;gap:4px}.field-path-navigation ol,.field-path-guide ol{grid-template-columns:1fr 1fr}.field-path-navigation li>a,.field-path-navigation li>span{min-height:74px;font-size:13px}.guide-article-body{padding:0 20px 52px}.guide-article-body>section{padding:38px 0}.guide-article-body>section>p{font-size:16px}.guide-topic-list>a,.guide-topic-list>article{min-height:235px}.treatment-path{grid-template-columns:1fr}.treatment-path>div{min-height:auto}.urgent-card-list article{padding:22px 18px 22px 63px}.urgent-card-list span{top:22px;left:17px}.page-terms{padding:25px 20px!important}.article-term-primer{margin:0 20px 12px;padding:24px 20px}.context-link-cards{margin:32px 0;padding:25px 20px}.glossary-hero{background:var(--surface-blue);padding:52px 20px 46px}.glossary-hero>p:not(.eyebrow){font-size:16px}.glossary-content{padding:10px 20px 62px}.glossary-section{padding:44px 0}.glossary-list>div{grid-template-columns:1fr;gap:5px;padding:17px 0}.glossary-list dd{font-size:15px}.glossary-note{padding:24px 20px}.guide-glossary-bridge{gap:22px;padding:50px 20px}}.unified-site-header{background:#fffffff5;gap:12px}.unified-site-header .brand,.unified-site-header .brand>span:last-child{min-width:0}.unified-site-header .brand-mark,.unified-site-header>nav{flex-shrink:0}.unified-site-header .brand strong{overflow-wrap:anywhere;line-height:1.5}.unified-site-header .nav-sitemap{color:var(--green);border-radius:99px;padding:8px 13px;border:1px solid var(--green)!important}.site-orientation{border-bottom:1px solid var(--line);background:#f3f7fb}.site-orientation>div{justify-content:space-between;align-items:center;gap:24px;max-width:1200px;min-height:48px;margin:0 auto;padding:8px 32px;display:flex}.site-orientation p{align-items:center;gap:10px;min-width:0;margin:0;display:flex}.site-orientation p span{color:var(--muted);letter-spacing:.08em;flex:none;font-size:11px;font-weight:700}.site-orientation p strong{color:var(--ink);text-overflow:ellipsis;white-space:nowrap;font-size:13px;overflow:hidden}.site-orientation nav{flex:none;gap:9px}.site-orientation nav a{color:var(--green);background:#fff;border:1px solid #cbd8e6;border-radius:99px;padding:5px 10px;font-size:12px;display:inline-flex}.top-author-credit{border-bottom:1px solid var(--line);background:#f5f8fc;grid-template-columns:minmax(230px,auto) minmax(260px,1fr) auto;align-items:center;gap:26px;max-width:1200px;margin:0 auto;padding:17px 32px;display:grid}.top-author-identity>span{color:var(--green);letter-spacing:.12em;margin-bottom:3px;font-size:10px;font-weight:800;display:block}.top-author-identity>a{align-items:baseline;gap:10px;width:fit-content;display:flex}.top-author-identity strong{font-family:var(--font-ui);font-size:20px}.top-author-identity small{color:var(--muted);font:600 11px/1.4 var(--font-ui)}.top-author-credit>p{color:var(--ink-2);margin:0;font-size:13px;line-height:1.7}.top-author-achievements{border:1px solid var(--green);color:var(--green);white-space:nowrap;background:#fff;justify-content:center;align-items:center;gap:8px;padding:10px 14px;font-size:13px;font-weight:700;transition:background .18s,color .18s;display:inline-flex}.top-author-achievements:hover,.top-author-achievements:focus-visible{background:var(--green);color:#fff}.site-entry-chooser{border-bottom:1px solid var(--line);grid-template-columns:.68fr 1.32fr;align-items:center;gap:48px;max-width:1200px;margin:0 auto;padding:36px 32px;display:grid}.site-entry-copy h2{font-family:var(--font-ui);margin:0;font-size:clamp(24px,3vw,34px);line-height:1.45}.site-entry-copy>p:last-child{color:var(--muted);margin:10px 0 0;font-size:14px;line-height:1.8}.site-entry-chooser>nav{grid-template-columns:1fr 1fr .72fr;gap:10px;display:grid}.site-entry-chooser>nav>a{border:1px solid var(--line);background:#fff;flex-direction:column;justify-content:center;min-height:126px;padding:18px;display:flex;position:relative}.site-entry-chooser>nav>a.is-current{border:2px solid var(--green);background:#f3f7fb}.site-entry-chooser>nav>a.is-current:after{content:"✓";color:var(--green);font-weight:800;position:absolute;top:13px;right:15px}.site-entry-chooser small{color:var(--green);font-size:11px;font-weight:700}.site-entry-chooser strong{font-family:var(--font-ui);margin-top:5px;font-size:17px;line-height:1.5}.site-entry-chooser span{color:var(--muted);margin-top:5px;font-size:12px;line-height:1.55}.site-entry-chooser .site-entry-all{background:var(--ink);color:#fff}.site-entry-chooser .site-entry-all small{color:#c0ddf5}.site-entry-chooser .site-entry-all span{color:#cbd8e6}.page-end-navigation{background:#f5f8fc;padding:68px max(32px,50vw - 480px)}.page-end-heading{max-width:720px}.page-end-heading h2{font-family:var(--font-ui);margin:0;font-size:clamp(30px,4vw,43px);line-height:1.45}.page-end-heading>p:last-child{color:var(--muted);margin:12px 0 0;font-size:16px;line-height:1.85}.page-end-related{grid-template-columns:1fr 1fr;gap:12px;margin-top:28px;display:grid}.page-end-related>a{border:1px solid var(--line);background:#fff;flex-direction:column;min-height:210px;padding:25px;display:flex}.page-end-related small{color:var(--green);font-size:11px;font-weight:700}.page-end-related strong{font-family:var(--font-ui);margin-top:16px;font-size:22px}.page-end-related p{color:var(--muted);margin:7px 0 18px;font-size:14px;line-height:1.75}.page-end-related span{color:var(--green);margin-top:auto;font-size:13px;font-weight:700}.page-end-homes{grid-template-columns:repeat(3,1fr);gap:8px;margin-top:14px;display:grid}.page-end-homes a{border:1px solid var(--green);min-height:50px;color:var(--green);text-align:center;background:0 0;justify-content:center;align-items:center;padding:10px 14px;font-size:13px;display:flex}.site-footer{color:#dce8f3;background:#102d4a;padding:0;font-size:14px;display:block}.site-footer-intro{border-bottom:1px solid #ffffff26;grid-template-columns:.8fr 1.2fr auto;align-items:end;gap:36px;max-width:1200px;margin:0 auto;padding:54px 32px 34px;display:grid}.site-footer-intro .eyebrow{color:#b5d8f5;grid-column:1/-1;margin-bottom:-24px}.site-footer-intro h2{color:#fff;font-family:var(--font-ui);margin:0;font-size:30px}.site-footer-intro>p:not(.eyebrow){color:#cbd8e6;margin:0;line-height:1.8}.site-footer-intro>a{color:#c0ddf5;border-bottom:1px solid #b5d8f5;padding-bottom:3px;font-weight:700}.site-footer-map{grid-template-columns:repeat(4,1fr);align-items:start;gap:34px;max-width:1200px;margin:0 auto;padding:38px 32px 45px;display:grid}.site-footer-map>div{flex-direction:column;gap:8px;display:flex}.site-footer-map strong{color:#fff;margin-bottom:5px;font-size:14px}.site-footer-map a{color:#cbd8e6;font-size:13px;font-weight:600}.site-footer-map a:hover{color:#fff}.site-footer-note{color:#849eb8;background:#0c233b;justify-content:space-between;gap:24px;padding:19px max(32px,50vw - 568px);font-size:11px;display:flex}.site-footer-note p{margin:0}.site-map-page{background:#fff}.directory-purpose-hero{background:var(--surface-blue);grid-template-columns:minmax(0,1.22fr) minmax(330px,.78fr);align-items:start;gap:clamp(46px,7vw,86px);padding:78px max(32px,50vw - 540px) 82px;display:grid}.directory-purpose-main .eyebrow{color:var(--green)}.directory-purpose-main h1{max-width:720px;font-family:var(--font-ui);letter-spacing:-.02em;margin:12px 0 0;font-size:clamp(44px,5.8vw,67px);font-weight:600;line-height:1.34}.directory-purpose-main>p:not(.eyebrow){max-width:720px;color:var(--ink-2);margin:19px 0 0;font-size:16px;line-height:2}.directory-purpose-main .directory-purpose-lead{color:var(--ink);margin-top:28px;font-size:18px;font-weight:650;line-height:1.95}.directory-purpose-actions{flex-wrap:wrap;gap:9px;margin-top:29px;display:flex}.directory-purpose-actions .button{min-height:50px}.directory-purpose-scope{border-top:5px solid var(--green);background:#fffffff0;padding:34px 32px;box-shadow:0 17px 50px #12345617}.directory-purpose-scope .eyebrow{color:var(--accent)}.directory-purpose-scope h2{font-family:var(--font-ui);margin:8px 0 0;font-size:clamp(28px,3.3vw,40px);font-weight:600;line-height:1.5}.directory-purpose-scope>p:not(.eyebrow){color:var(--ink-2);margin:17px 0 0;font-size:14px;line-height:1.9}.directory-purpose-scope ol{border-top:1px solid var(--line);margin:25px 0 0;padding:0;list-style:none}.directory-purpose-scope li{border-bottom:1px solid var(--line);grid-template-columns:32px 1fr;align-items:center;gap:12px;min-height:58px;display:grid}.directory-purpose-scope li span{color:var(--accent);font:700 15px/1 var(--font-ui)}.directory-purpose-scope li strong{font-size:13px;line-height:1.55}.directory-purpose-byline{border-top:1px solid var(--line);gap:5px;margin-top:25px;padding-top:19px;display:grid}.directory-purpose-byline>span{color:var(--muted);letter-spacing:.08em;font-size:11px;font-weight:700}.directory-purpose-byline a{width:fit-content;color:var(--green);font-family:var(--font-ui);font-size:20px;font-weight:700}.directory-purpose-byline small{color:var(--muted);font-family:var(--font-ui);margin-left:8px;font-size:11px;font-weight:600}.directory-author-english{color:var(--green);font-family:var(--font-ui);letter-spacing:.03em;margin:8px 0 0;font-size:16px}.directory-author-role{color:var(--ink-2);margin:24px 0 0;font-size:15px;font-weight:650;line-height:1.85}.directory-author-links{flex-wrap:wrap;gap:9px;margin-top:26px;display:flex}.directory-author-links .button{min-height:48px}.directory-author-summary{border-top:1px solid var(--line);background:#f5f8fc;grid-template-columns:minmax(280px,.72fr) minmax(0,1.28fr);align-items:center;gap:clamp(45px,7vw,82px);padding:68px max(32px,50vw - 540px);display:grid}.directory-author-summary-identity{border-left:5px solid var(--accent);padding:23px 0 23px 29px}.directory-author-summary-identity h2{font-family:var(--font-ui);margin:8px 0 0;font-size:clamp(34px,4vw,47px);font-weight:600;line-height:1.3}.directory-author-summary-copy h3{font-family:var(--font-ui);margin:0;font-size:clamp(26px,3.3vw,38px);font-weight:600;line-height:1.5}.directory-author-summary-copy>p{color:var(--ink-2);margin:18px 0 0;font-size:16px;line-height:1.95}.site-map-hero{background:var(--surface-blue);padding:74px max(32px,50vw - 540px) 68px}.site-map-hero h1{font-family:var(--font-ui);margin:0;font-size:clamp(40px,5.7vw,64px);font-weight:600;line-height:1.35}.site-map-hero>p:last-child{max-width:740px;color:var(--ink-2);margin:21px 0 0;font-size:18px;line-height:1.9}.directory-intro{scroll-margin-top:82px}.directory-intro h2{font-family:var(--font-ui);margin:0;font-size:clamp(36px,5vw,56px);font-weight:600;line-height:1.4}.directory-intro>p:not(.eyebrow){max-width:780px;color:var(--ink-2);margin:21px 0 0;font-size:18px;line-height:1.9}.directory-jump-links{grid-template-columns:repeat(4,1fr);gap:8px;max-width:1080px;margin-top:30px;display:grid}.directory-jump-links a{border:1px solid var(--green);min-height:62px;color:var(--green);text-align:center;background:#ffffffe0;justify-content:center;align-items:center;padding:12px;font-size:13px;font-weight:700;display:flex}.directory-jump-links a:hover{background:var(--green);color:#fff}.site-map-moved .button{margin-top:28px;display:inline-flex}.site-map-moved>p:not(.eyebrow){max-width:740px;color:var(--ink-2);margin:21px 0 0;font-size:18px;line-height:1.9}.reading-paths,.complete-page-list{padding:72px max(32px,50vw - 540px)}.reading-paths{background:#f5f8fc}.site-map-heading h2{font-family:var(--font-ui);margin:0;font-size:clamp(31px,4vw,44px)}.site-map-heading>p:last-child{color:var(--muted)}.reading-path-grid{grid-template-columns:repeat(3,1fr);gap:12px;margin-top:30px;display:grid}.reading-path-grid article{border:1px solid var(--line);background:#fff;padding:25px}.reading-path-grid article>span{min-height:52px;color:var(--ink);font-family:var(--font-ui);font-size:18px;font-weight:700;line-height:1.5;display:block}.reading-path-grid ol{counter-reset:path;margin:18px 0 0;padding:0;list-style:none}.reading-path-grid li{border-top:1px solid var(--line);color:var(--muted);counter-increment:path;padding:10px 0 10px 34px;font-size:14px;position:relative}.reading-path-grid li:before{content:counter(path);background:var(--green);color:#fff;border-radius:50%;place-items:center;width:22px;height:22px;font-size:11px;font-weight:700;display:grid;position:absolute;top:10px;left:0}.reading-path-grid a{color:var(--green);font-weight:700}.site-map-groups{border-top:1px solid var(--line);margin-top:32px}.site-map-groups>section{border-bottom:1px solid var(--line);grid-template-columns:.78fr 1.22fr;gap:48px;padding:45px 0;scroll-margin-top:80px;display:grid}.site-map-group-title{grid-template-columns:42px 1fr;gap:17px;display:grid}.site-map-group-title>span{color:var(--accent);font:700 22px/1 var(--font-ui)}.site-map-group-title h3{font-family:var(--font-ui);margin:0;font-size:25px;line-height:1.5}.site-map-group-title p{color:var(--muted);font-size:14px;line-height:1.8}.site-map-groups nav{align-items:stretch;gap:0;display:grid}.site-map-groups nav a{border-bottom:1px solid var(--line);grid-template-columns:210px 1fr 20px;align-items:center;gap:18px;min-height:58px;padding:10px 6px;display:grid;position:relative}.site-map-groups nav a:first-child{border-top:1px solid var(--line)}.site-map-groups nav strong{color:var(--green);font-size:14px}.site-map-groups nav span{color:var(--muted);font-size:13px;font-weight:600}.site-map-groups nav b{color:var(--green)}.site-map-reminder{border-left:5px solid var(--accent);background:#f5f8fc;max-width:1080px;margin:0 auto 78px;padding:30px 32px}.site-map-reminder>strong{font-family:var(--font-ui);font-size:24px}.site-map-reminder>p{color:var(--ink-2);line-height:1.9}.site-map-reminder>div{flex-wrap:wrap;gap:10px;margin-top:20px;display:flex}@media (width<=1040px){.unified-site-header nav a:not(.nav-sitemap):not(.nav-urgent){display:none}.unified-site-header nav .nav-sitemap,.unified-site-header nav .nav-urgent{display:inline-flex}.top-author-credit{grid-template-columns:minmax(230px,auto) 1fr;gap:10px 24px}.top-author-achievements{grid-column:1/-1;width:fit-content}.site-entry-chooser{grid-template-columns:1fr;gap:22px}.site-footer-intro{grid-template-columns:1fr;align-items:start;gap:12px}.site-footer-intro .eyebrow{grid-column:1;margin-bottom:0}}@media (width<=900px){.site-orientation nav a,.site-entry-chooser nav a,.page-end-navigation nav a,.site-footer nav a,.site-map-page nav a{display:flex}.site-footer-map{grid-template-columns:1fr 1fr}.reading-path-grid{grid-template-columns:1fr}.site-map-groups>section{grid-template-columns:1fr;gap:20px}.directory-purpose-hero,.directory-author-summary{grid-template-columns:1fr;gap:34px}.directory-purpose-scope{max-width:720px}.directory-jump-links{grid-template-columns:1fr 1fr}.profile-chemotherapy-feature{grid-template-columns:1fr}}@media (width<=700px){.site-orientation>div{flex-direction:column;align-items:flex-start;gap:7px;padding:9px 16px 11px}.site-orientation p{width:100%}.site-orientation p strong{white-space:normal}.site-orientation nav{gap:5px;width:100%}.site-orientation nav a{flex:1;justify-content:center;padding-inline:5px;font-size:11px}.top-author-credit{grid-template-columns:1fr;gap:9px;padding:17px 20px 19px}.top-author-identity>a{flex-wrap:wrap;gap:2px 9px}.top-author-credit>p{font-size:12px}.top-author-achievements{grid-column:auto;width:100%}.site-entry-chooser{padding:27px 20px}.site-entry-chooser>nav{grid-template-columns:1fr;width:100%}.site-entry-chooser>nav>a{min-height:104px}.page-end-navigation{padding:52px 20px}.page-end-related{grid-template-columns:1fr}.page-end-related>a{min-height:180px}.page-end-homes{grid-template-columns:1fr}.site-footer-map{grid-template-columns:1fr;padding:30px 20px 36px}.site-footer-intro{padding:42px 20px 28px}.site-footer-note{flex-direction:column;align-items:flex-start;padding:17px 20px}.site-map-hero{background:var(--surface-blue);padding:52px 20px}.site-map-hero>p:last-child{font-size:16px}.reading-paths,.complete-page-list{padding:52px 20px}.site-map-groups nav a{grid-template-columns:1fr 22px;gap:5px 10px;padding:13px 4px}.site-map-groups nav strong,.site-map-groups nav span{grid-column:1}.site-map-groups nav b{grid-area:1/2/3;align-self:center}.site-map-reminder{margin:0 20px 58px;padding:24px 20px}.directory-purpose-hero{background:var(--surface-blue);gap:30px;padding:50px 20px 56px}.directory-purpose-main h1{font-size:clamp(38px,11vw,51px)}.directory-purpose-main .directory-purpose-lead{font-size:17px;line-height:1.9}.directory-purpose-main>p:not(.eyebrow){font-size:15px;line-height:1.9}.directory-purpose-actions{flex-direction:column}.directory-purpose-actions .button{width:100%}.directory-purpose-scope{padding:28px 22px}.directory-purpose-byline small{margin:3px 0 0;display:block}.directory-author-summary{gap:30px;padding:52px 20px 58px}.directory-author-summary-identity{border-left-width:4px;padding:22px 0 22px 21px}.directory-author-links{flex-direction:column}.directory-author-links .button{width:100%}.directory-jump-links{grid-template-columns:1fr;gap:6px}.directory-jump-links a{min-height:54px}.chemotherapy-fact-box{grid-template-columns:1fr}.chemotherapy-fact-box>div{min-height:auto}.chemotherapy-research-links a{grid-template-columns:1fr;gap:6px}.chemotherapy-research-links span{white-space:normal}}@media (width<=620px){.unified-site-header nav{gap:6px}.unified-site-header nav .nav-sitemap,.unified-site-header nav .nav-urgent{padding:6px 8px;font-size:10px}.unified-site-header .brand small{font-size:8px;display:block}}.global-page-controls{right:max(18px, env(safe-area-inset-right));bottom:max(18px, env(safe-area-inset-bottom));z-index:80;flex-direction:column;gap:8px;font-size:13px;display:flex;position:fixed}.global-page-controls a{min-width:146px;min-height:48px;color:var(--ink);-webkit-backdrop-filter:blur(10px);backdrop-filter:blur(10px);background:#fffffff7;border-radius:999px;align-items:center;gap:9px;padding:8px 15px;box-shadow:0 7px 24px #102d4a29;border:1px solid #12345633!important;display:flex!important}.global-page-controls a:first-child{background:var(--ink);color:#fff;border-color:var(--ink)!important}.global-page-controls a:hover,.global-page-controls a:focus-visible{background:var(--green);color:#fff;transform:translateY(-1px);border-color:var(--green)!important}.global-page-controls span{background:#1e57911f;border-radius:50%;flex:0 0 22px;place-items:center;width:22px;height:22px;font-size:16px;font-weight:800;line-height:1;display:grid}.global-page-controls a:first-child span,.global-page-controls a:hover span,.global-page-controls a:focus-visible span{background:#ffffff29}.global-page-controls strong{white-space:nowrap;font-size:13px;line-height:1.3}@media (width<=700px){.global-page-controls{right:max(10px, env(safe-area-inset-right));bottom:max(9px, env(safe-area-inset-bottom));left:max(10px, env(safe-area-inset-left));grid-template-columns:1fr 1fr;gap:7px;display:grid}.global-page-controls a{justify-content:center;min-width:0;min-height:52px;padding:8px 10px}.global-page-controls strong{font-size:13px}.site-footer-note{padding-bottom:calc(88px + env(safe-area-inset-bottom))}}.directory-task-hero{background:var(--surface-blue);grid-template-columns:minmax(0,1.12fr) minmax(340px,.88fr);align-items:start;gap:clamp(42px,6vw,78px);padding:68px max(32px,50vw - 560px) 72px;display:grid}.directory-task-main>.eyebrow,.directory-search-panel>.eyebrow{color:var(--green);letter-spacing:.08em;font-family:inherit;font-size:13px}.directory-task-main h1{font-family:var(--font-ui);letter-spacing:-.02em;margin:10px 0 0;font-size:clamp(45px,5.8vw,68px);font-weight:600;line-height:1.32}.directory-task-lead{max-width:680px;color:var(--ink-2);margin:24px 0 0;font-size:18px;font-weight:650;line-height:1.9}.directory-welcome-note{border-left:4px solid var(--accent);background:#ffffffb8;max-width:690px;margin-top:24px;padding:18px 20px}.directory-welcome-note strong{color:var(--ink);font-size:15px;display:block}.directory-welcome-note p{color:var(--ink-2);margin:7px 0 0;font-size:14px;line-height:1.8}.directory-task-choice{border-top:1px solid #12345629;margin-top:31px;padding-top:25px}.directory-task-choice p{color:var(--green);letter-spacing:.08em;margin:0;font-size:12px;font-weight:800}.directory-task-choice h2{font-family:var(--font-ui);margin:7px 0 0;font-size:clamp(25px,3vw,34px);font-weight:600;line-height:1.5}.patient-task-grid{grid-template-columns:1fr 1fr;gap:10px;margin-top:28px;display:grid}.patient-task-grid>a{border:1px solid var(--line);background:#fffffff0;flex-direction:column;justify-content:center;min-height:142px;padding:22px 22px 20px 58px;display:flex;position:relative;box-shadow:0 10px 28px #1234560e}.patient-task-grid>a>span{color:var(--accent);font:700 17px/1 var(--font-ui);position:absolute;top:24px;left:20px}.patient-task-grid>a>strong{color:var(--green);font-family:var(--font-ui);font-size:21px;line-height:1.5}.patient-task-grid>a>small{color:var(--muted);margin-top:7px;font-size:13px;line-height:1.6}.patient-task-grid>a:hover,.patient-task-grid>a:focus-visible{border-color:var(--green);transform:translateY(-2px);box-shadow:0 16px 38px #12345617}.patient-task-grid>a.patient-task-urgent{background:#fff5f2;border-color:#d9aaa2}.patient-task-grid>a.patient-task-urgent>strong{color:#7d352e}.patient-task-grid>a.patient-task-urgent>span{color:#9b443b}.ipmn-priority-link{border-left:4px solid var(--green);background:#ffffffad;margin:18px 0 0;padding:15px 18px;font-size:14px;line-height:1.7}.ipmn-priority-link a{color:var(--green);text-underline-offset:4px;margin-left:6px;font-weight:800;text-decoration:underline}.directory-search-panel{border-top:5px solid var(--green);background:#fffffff5;padding:32px 30px;box-shadow:0 18px 55px #1234561a}.directory-search-panel h2{font-family:var(--font-ui);margin:7px 0 0;font-size:clamp(28px,3.2vw,38px);font-weight:600;line-height:1.5}.site-search{margin-top:22px}.site-search>label{color:var(--ink);margin-bottom:7px;font-size:14px;font-weight:800;display:block}.site-search-input-row{border:2px solid var(--green);background:#fff;grid-template-columns:34px 1fr;align-items:center;min-height:58px;display:grid}.site-search-input-row>span{color:var(--green);text-align:center;font-size:25px}.site-search-input-row input{width:100%;min-width:0;min-height:54px;color:var(--ink);font:inherit;background:0 0;border:0;outline:0;padding:9px 12px 9px 4px;font-size:16px}.site-search-input-row:focus-within{outline-offset:2px;outline:3px solid #1e57912e}.site-search-help{color:var(--muted);margin:8px 0 0;font-size:12px;line-height:1.6}.site-search-results{margin-top:13px}.site-search-results>p{color:var(--muted);margin:0 0 8px;font-size:13px}.site-search-results nav{gap:6px;display:grid}.site-search-results nav a{border:1px solid var(--line);background:#f5f8fc;flex-direction:column;padding:11px 13px;display:flex}.site-search-results nav strong{color:var(--green);font-size:14px}.site-search-results nav span{color:var(--muted);margin-top:3px;font-size:12px;line-height:1.5}.site-search-empty a{color:var(--green);font-weight:800;text-decoration:underline}.directory-search-author{border-top:1px solid var(--line);gap:5px;margin-top:25px;padding-top:20px;display:grid}.directory-search-author>span{color:var(--muted);letter-spacing:.08em;font-size:11px;font-weight:800}.directory-search-author>a:first-of-type{flex-wrap:wrap;align-items:baseline;gap:3px 9px;width:fit-content;display:flex}.directory-search-author strong{color:var(--ink);font-family:var(--font-ui);font-size:21px}.directory-search-author small{color:var(--muted);font:600 11px/1.4 var(--font-ui)}.directory-search-author>a:last-child{width:fit-content;color:var(--green);margin-top:6px;font-size:13px;font-weight:800}.directory-purpose-section{border-bottom:1px solid var(--line);background:#fff;grid-template-columns:minmax(0,1.12fr) minmax(330px,.88fr);align-items:start;gap:clamp(46px,7vw,86px);padding:70px max(32px,50vw - 540px);display:grid}.directory-purpose-section .directory-purpose-main h2{font-family:var(--font-ui);margin:9px 0 0;font-size:clamp(35px,4.7vw,53px);font-weight:600;line-height:1.45}.directory-purpose-scope li{grid-template-columns:54px 1fr;padding:8px 0}.directory-purpose-scope li span{font-family:inherit;font-size:12px;font-weight:800}.individual-site-note{border-left:3px solid var(--accent);background:var(--cream);padding:15px 16px;color:var(--ink-2)!important;font-size:13px!important}.editorial-policy-inline{width:fit-content;color:var(--green);text-underline-offset:3px;margin-top:6px;font-size:12px;font-weight:800;text-decoration:underline;display:block}.review-disclosure{border-top:1px solid var(--line);margin:25px 0 0}.review-disclosure>div{border-bottom:1px solid var(--line);grid-template-columns:145px 1fr;gap:18px;padding:13px 0;display:grid}.review-disclosure dt{color:var(--green);font-size:13px;font-weight:800}.review-disclosure dd{color:var(--ink-2);margin:0;font-size:14px;line-height:1.75}.editorial-policy-link{color:var(--green);text-underline-offset:4px;margin-top:18px;font-size:14px;font-weight:800;text-decoration:underline;display:inline-block}.inline-evidence-link{border-left:3px solid var(--green);background:#f3f7fb;flex-wrap:wrap;align-items:baseline;gap:8px 15px;padding:14px 16px;display:flex;color:var(--ink-2)!important;margin:18px 0 0!important;font-size:13px!important;line-height:1.7!important}.inline-evidence-link strong{color:var(--ink)}.inline-evidence-link a{color:var(--green);text-underline-offset:3px;font-weight:800;text-decoration:underline}.editorial-policy-page{background:var(--paper)}.editorial-policy-hero{background:var(--surface-blue);padding:66px max(32px,50vw - 490px) 58px}.editorial-policy-hero h1{font-family:var(--font-ui);margin:12px 0 0;font-size:clamp(40px,5.4vw,62px);font-weight:600;line-height:1.4}.editorial-policy-hero>p:not(.eyebrow){max-width:800px;color:var(--ink-2);margin:23px 0 0;font-size:18px;line-height:1.9}.policy-summary{border:1px solid var(--line);background:var(--line);grid-template-columns:repeat(3,1fr);gap:1px;margin:30px 0 0;display:grid}.policy-summary>div{background:#ffffffed;padding:17px 18px}.policy-summary dt{color:var(--green);font-size:12px;font-weight:800}.policy-summary dd{color:var(--ink);margin:5px 0 0;font-size:14px;line-height:1.6}.editorial-policy-body{max-width:980px;margin:0 auto;padding:25px 32px 78px}.editorial-policy-body>section{border-bottom:1px solid var(--line);padding:56px 0}.editorial-policy-body>section h2{font-family:var(--font-ui);margin:0;font-size:clamp(29px,4vw,42px);font-weight:600;line-height:1.5}.editorial-policy-body>section>p:not(.eyebrow){color:var(--ink-2);margin:20px 0 0;font-size:16px;line-height:1.95}.policy-priority-list{border-top:1px solid var(--line);counter-reset:policy-priority;gap:0;margin:28px 0 0;padding:0;list-style:none;display:grid}.policy-priority-list li{border-bottom:1px solid var(--line);counter-increment:policy-priority;grid-template-columns:minmax(230px,.8fr) 1.2fr;gap:25px;padding:20px 18px 20px 58px;display:grid;position:relative}.policy-priority-list li:before{content:counter(policy-priority);background:var(--green);color:#fff;border-radius:50%;place-items:center;width:27px;height:27px;font-size:12px;font-weight:800;display:grid;position:absolute;top:20px;left:17px}.policy-priority-list strong{color:var(--ink);font-size:15px}.policy-priority-list span{color:var(--muted);font-size:14px;line-height:1.75}.policy-caution{border-left:4px solid var(--accent);background:var(--cream);margin-top:25px;padding:22px 24px}.policy-caution strong{font-family:var(--font-ui);font-size:20px}.policy-caution p{color:var(--ink-2);margin:9px 0 0;font-size:15px;line-height:1.85}.policy-three-levels{grid-template-columns:repeat(3,1fr);gap:10px;margin-top:28px;display:grid}.policy-three-levels article{border:1px solid var(--line);background:#fff;padding:24px}.policy-three-levels span{color:var(--green);letter-spacing:.08em;font-size:11px;font-weight:800}.policy-three-levels h3{font-family:var(--font-ui);margin:13px 0 8px;font-size:21px}.policy-three-levels p{color:var(--muted);margin:0;font-size:14px;line-height:1.75}.policy-process{border:1px solid var(--line);background:var(--line);grid-template-columns:repeat(4,1fr);gap:1px;margin-top:28px;display:grid}.policy-process>div{background:#fff;min-height:235px;padding:22px}.policy-process span{background:var(--green);color:#fff;border-radius:50%;place-items:center;width:30px;height:30px;font-size:12px;font-weight:800;display:grid}.policy-process strong{font-family:var(--font-ui);margin-top:25px;font-size:18px;line-height:1.6;display:block}.policy-process p{color:var(--muted);margin:9px 0 0;font-size:13px;line-height:1.75}.policy-actions{flex-wrap:wrap;gap:10px;margin-top:27px;display:flex}.site-map-groups nav strong{font-size:16px}.site-map-groups nav span{font-size:14px;line-height:1.6}.unified-site-header nav{font-size:14px}.site-orientation nav a{font-size:13px}.site-footer-note a{color:#b9cfe3;text-underline-offset:3px;text-decoration:underline}@media (width<=980px){.directory-task-hero,.directory-purpose-section{grid-template-columns:1fr}.directory-search-panel{max-width:720px}.policy-process{grid-template-columns:1fr 1fr}}@media (width<=700px){.directory-task-hero{background:var(--surface-blue);gap:28px;padding:43px 20px 52px}.directory-task-main h1{font-size:clamp(39px,11vw,52px)}.directory-task-lead{font-size:17px;line-height:1.85}.directory-welcome-note{padding:17px 16px}.directory-welcome-note strong{font-size:15px}.directory-welcome-note p{font-size:14px}.directory-task-choice{margin-top:27px;padding-top:22px}.directory-task-choice h2{font-size:29px}.patient-task-grid{grid-template-columns:1fr}.patient-task-grid>a{min-height:116px;padding:19px 18px 18px 57px}.patient-task-grid>a>strong{font-size:20px}.patient-task-grid>a>small{font-size:14px}.directory-search-panel{padding:27px 21px}.site-search>label{font-size:15px}.site-search-input-row input{font-size:16px}.directory-purpose-section{gap:28px;padding:52px 20px}.directory-purpose-section .directory-purpose-main h2{font-size:36px}.review-disclosure>div{grid-template-columns:1fr;gap:4px}.editorial-policy-hero{background:var(--surface-blue);padding:46px 20px 48px}.editorial-policy-hero h1{font-size:37px}.editorial-policy-hero>p:not(.eyebrow){font-size:16px}.policy-summary,.policy-three-levels,.policy-process{grid-template-columns:1fr}.editorial-policy-body{padding:15px 20px 58px}.editorial-policy-body>section{padding:46px 0}.policy-priority-list li{grid-template-columns:1fr;gap:7px;padding-left:58px}.policy-process>div{min-height:auto}.unified-site-header nav .nav-sitemap,.unified-site-header nav .nav-urgent,.site-orientation nav a{font-size:12px}}.patient-summary{color:var(--ink);margin:1.8rem 0}.patient-summary h2{margin:0 0 .8rem;font-size:1.25rem;line-height:1.6}.patient-summary-grid{grid-template-columns:repeat(3,minmax(0,1fr));gap:.75rem;display:grid}.patient-summary-grid a{border:1px solid #9ab4ce;border-top:4px solid var(--accent);color:var(--ink);background:#fff;flex-direction:column;gap:.7rem;min-width:0;padding:1.2rem;text-decoration:none;display:flex}.patient-summary-grid strong{font-size:1.12rem;line-height:1.65}.patient-summary-grid span{font-size:1rem;line-height:1.8}.patient-summary-grid small{color:var(--green);text-underline-offset:.2rem;margin-top:auto;font-size:.95rem;text-decoration:underline}.patient-summary a:focus-visible,.patient-next-link:focus-visible,.patient-evidence summary:focus-visible,.article-terms-disclosure summary:focus-visible{outline-offset:4px;outline:3px solid #165a93}.article-terms-disclosure{max-width:900px;margin:1rem auto;padding:0 2rem}.article-terms-disclosure>summary{cursor:pointer;border:1px solid var(--line);padding:1rem;font-size:1rem;line-height:1.8}.article-terms-disclosure .article-term-primer{margin:0}.patient-answer{border-left:5px solid var(--accent);background:#edf4fa;margin:1rem 0;padding:1.5rem}.patient-answer>strong{font-size:1.2rem;line-height:1.8}.patient-answer p,.patient-choice-grid p,.patient-evidence p{color:var(--ink-2);margin:.75rem 0 0;font-size:1.0625rem;line-height:1.95}.patient-choice-grid{grid-template-columns:repeat(2,minmax(0,1fr));gap:1rem;margin:1.25rem 0;display:grid}.patient-choice-grid article{border:1px solid var(--line);padding:1.25rem}.patient-choice-grid h3{margin:0;font-size:1.125rem;line-height:1.7}.patient-evidence{border:1px solid #9ab4ce;margin:1.5rem 0;scroll-margin-top:100px}.patient-evidence summary{cursor:pointer;padding:1.2rem;font-size:1.0625rem;font-weight:700;line-height:1.8}.patient-evidence[open] summary{border-bottom:1px solid var(--line)}.patient-evidence>div{padding:0 1.25rem 1.25rem}.patient-evidence a{overflow-wrap:anywhere;text-underline-offset:.2rem;text-decoration:underline}.patient-checklist{margin:1.25rem 0;padding-left:1.6rem}.patient-checklist li{border-bottom:1px solid var(--line);padding:.65rem 0;font-size:1.0625rem;line-height:1.9}.patient-next-link{border:1px solid var(--green);color:var(--green);flex-direction:column;gap:.6rem;margin-top:1.5rem;padding:1.25rem;line-height:1.8;text-decoration:none;display:flex}.patient-next-link strong{font-size:1.125rem}.patient-next-link span{text-underline-offset:.2rem;font-size:1rem;text-decoration:underline}@media (width<=720px){.patient-summary-grid,.patient-choice-grid{grid-template-columns:1fr}.patient-summary-grid a{gap:.35rem;padding:1rem 1.1rem}.article-terms-disclosure{padding:0 1.25rem}}@media print{.patient-summary-grid,.patient-choice-grid{grid-template-columns:1fr}.patient-evidence>div{display:block}}.home-quick-menu{border-bottom:1px solid var(--line);background:#edf4fa;padding:20px clamp(20px,5vw,76px) 24px;display:block}.home-quick-menu h2{margin:0 0 12px;font-size:1rem;line-height:1.6}.home-quick-menu>div{grid-template-columns:repeat(3,minmax(0,1fr));gap:10px;display:grid}.home-quick-menu a{border:1px solid var(--green);min-width:0;min-height:52px;color:var(--green);text-align:center;word-break:normal;overflow-wrap:break-word;text-wrap:balance;background:#fff;border-radius:8px;justify-content:center;align-items:center;padding:10px 12px;font-size:1rem;line-height:1.5;display:flex}.home-quick-menu a:hover{background:var(--green);color:#fff}.home-quick-menu a:focus-visible{outline:3px solid var(--green);outline-offset:3px}.directory-home-page :is(#quick-menu,#site-search,.site-map-groups>section){scroll-margin-top:7rem}@media (width<=620px){.home-quick-menu{padding:16px 20px 20px}.home-quick-menu>div{grid-template-columns:repeat(2,minmax(0,1fr));gap:8px}.home-quick-menu a{padding:10px 8px}.directory-home-page :is(#quick-menu,#site-search,.site-map-groups>section){scroll-margin-top:12rem}}@media (width>=621px){.directory-home-page .directory-task-main h1{font-size:clamp(2.25rem,4vw,3.25rem);line-height:1.5}.directory-home-page .directory-purpose-main h2{letter-spacing:0;font-size:clamp(1.75rem,3vw,2.375rem);line-height:1.6}.directory-home-page .directory-intro h2{font-size:clamp(2rem,3.5vw,2.5rem);line-height:1.6}.directory-home-page :is(.directory-purpose-scope,.directory-search-panel) h2{font-size:clamp(1.625rem,2.4vw,2rem);line-height:1.6}.directory-home-page .site-map-heading h2{font-size:clamp(1.75rem,2.8vw,2.125rem);line-height:1.6}.directory-home-page .home-heading-phrase{max-width:100%;display:inline-block}}@media (width<=620px){.unified-site-header{flex-wrap:wrap;gap:8px 12px}.unified-site-header .brand{flex:100%}.unified-site-header .brand strong{overflow-wrap:normal;font-size:1rem;line-height:1.45}.unified-site-header .brand-title-part{max-width:100%;display:inline-block}.unified-site-header .brand small{font-size:.75rem}.unified-site-header>nav{flex-wrap:wrap;justify-content:flex-end;width:100%}main :is(h1,h2,h3){word-break:normal;overflow-wrap:break-word;line-break:strict;text-wrap:balance}main :is(h1,h2,h3) br{display:none}.directory-task-main h1{letter-spacing:0;font-size:clamp(1.5rem,6.9vw,1.875rem);line-height:1.65}.directory-task-main h1 br{display:initial}.article-hero h1,.guide-article-hero h1,.waiting-guide-heading h1,.site-map-hero h1,.glossary-hero h1,.editorial-policy-hero h1{letter-spacing:0;font-size:clamp(1.625rem,7.3vw,1.875rem);line-height:1.6}.responsive-title-phrase{vertical-align:top;max-width:100%;display:inline-block}.responsive-title-reading{font-size:.75em;line-height:2.13}.responsive-title-divider{height:0;display:block;overflow:hidden}.directory-purpose-section .directory-purpose-main h2,.directory-intro h2,.directory-purpose-scope h2,.directory-search-panel h2,.directory-task-choice h2,.article-body h2,.guide-article-body h2,.site-map-heading h2,.page-end-heading h2{letter-spacing:0;font-size:clamp(1.375rem,6.1vw,1.625rem);line-height:1.65}}.home-welcome{background:#edf4fa;grid-template-columns:minmax(0,1.35fr) minmax(0,.85fr);gap:3rem;padding:3rem max(24px,50vw - 560px);display:grid}.home-welcome h1{font-family:var(--font-ui);letter-spacing:0;text-wrap:pretty;margin:.5rem 0 1.25rem;font-size:clamp(1.8rem,3vw,2.5rem);font-weight:600;line-height:1.65}.home-welcome h1>span{display:block}.home-welcome p{margin:1rem 0;font-size:1rem;line-height:1.95}.home-welcome .eyebrow{color:var(--green);margin:0;font-size:.875rem}.home-welcome .home-welcome-lead{font-size:1.125rem;font-weight:600}.home-welcome-lead>span{max-width:100%;display:inline-block}.home-purpose-link{color:var(--green);text-underline-offset:.25em;padding:.6rem 0;font-weight:700;text-decoration:underline;display:inline-block}.home-welcome .home-welcome-credit{margin-bottom:0;font-size:.875rem}.home-welcome-credit>span{margin-left:.5rem;display:inline-block}.home-welcome-credit a{text-underline-offset:.2em;font-weight:700;text-decoration:underline}.home-question-guide{border-top:4px solid var(--green);background:#fff;align-self:start;padding:1.5rem}.home-question-guide h2{margin:0 0 .75rem;font-size:1.125rem}.home-question-guide>a{border-bottom:1px solid var(--line);flex-direction:column;gap:.3rem;padding:1rem 0;display:flex}.home-question-guide a>span,.home-question-guide a>small{font-size:.875rem}.home-question-guide a>span{color:var(--muted)}.home-question-guide a>strong{font-size:1.0625rem}.home-question-guide a>small{color:var(--green);text-underline-offset:.2em;text-decoration:underline}.home-question-guide p{margin-bottom:0;font-size:.9375rem}.home-question-guide p a{color:var(--blue);font-size:inherit;text-underline-offset:.2em;text-decoration:underline}.home-start-actions{flex-wrap:wrap;gap:.65rem;margin:1.25rem 0;display:flex}.home-start-actions .button{min-height:48px;font-size:.9375rem}.home-welcome .home-reader-note{border-top:1px solid var(--line);padding-top:1rem;font-size:.9375rem}.home-directory-group[open] summary{border-bottom:1px solid var(--line);background:var(--surface-blue)}#ipmn{scroll-margin-top:11rem}#all-pages,#site-purpose,#site-search{scroll-margin-top:8rem}.home-welcome a:focus-visible,.home-purpose a:focus-visible,.home-directory-group a:focus-visible{outline-offset:3px;outline:3px solid #165a93}.home-quick-menu{border-bottom:1px solid var(--line)}.directory-task-hero.home-search-section{background:#fff;gap:2.5rem;padding-top:2.5rem;padding-bottom:2.5rem}.home-search-section .directory-task-main>h2{margin:0;font-size:1.5rem;line-height:1.65}.home-search-section .directory-search-panel{box-shadow:none;background:#f3f7fb;padding:1.5rem}.home-search-section .directory-search-panel h2{font-size:1.5rem}.home-search-section .directory-search-author{display:none}.home-search-section .directory-welcome-note{background:#f5f8fc;margin-top:1rem;padding:1rem}.home-search-section .directory-welcome-note p{font-size:1rem}.home-urgent-note{color:#7d352e;background:#fff5f2;border-left:3px solid #943e30;padding:.75rem 1rem;font-size:1rem;font-weight:700}.home-purpose{border-block:1px solid var(--line);background:#f5f8fc;padding:2.5rem max(24px,50vw - 540px)}.home-purpose h2{font-family:var(--font-ui);margin:.5rem 0 1rem;font-size:clamp(1.5rem,2.7vw,2rem);line-height:1.6}.home-purpose .directory-purpose-main>p:not(.eyebrow){max-width:54em;font-size:1rem;line-height:1.95}.home-purpose-cards{grid-template-columns:repeat(3,minmax(0,1fr));gap:1rem;margin:1.75rem 0;display:grid}.home-purpose-cards article{border-top:3px solid var(--green);background:#fff;padding:1.25rem}.home-purpose-cards article>span{color:var(--green);font-size:.875rem;font-weight:700}.home-purpose-cards h3{margin:.5rem 0;font-size:1.125rem;line-height:1.7}.home-purpose-cards p{margin:0;font-size:1rem;line-height:1.85}.home-editor-note{border-block:1px solid var(--line)}.home-editor-note summary{cursor:pointer;padding:1rem 0;font-size:1rem;font-weight:700}.home-editor-note>div{max-width:54em;padding-bottom:.75rem;font-size:1rem}.home-purpose .individual-site-note{margin-bottom:0;font-size:.875rem!important}.directory-home-page .reading-paths,.directory-home-page .complete-page-list{padding-top:2.5rem;padding-bottom:2.5rem}.home-directory-grid{border:0;grid-template-columns:repeat(2,minmax(0,1fr));align-items:start;gap:1rem;display:grid}.home-directory-group{background:#fff;border:1px solid #9ab4ce;min-width:0;scroll-margin-top:8rem}.home-directory-group summary{cursor:pointer;color:var(--green);padding:1.25rem;font-size:1.125rem;font-weight:700;display:list-item}.home-directory-group summary>span:last-child{display:inline}.home-directory-group summary strong{font-size:1.125rem;line-height:1.7}.home-directory-group summary small{color:var(--muted);margin:.4rem 0 0 2.2rem;font-size:.875rem;font-weight:600;display:block}.directory-group-number{padding-right:.5rem;font-size:.875rem;display:inline-block}.home-directory-group>p{margin:0 0 1rem;padding:0 1.25rem;font-size:1rem}.home-directory-group>nav{grid-template-columns:1fr;gap:0;padding:0 1.25rem 1.25rem;display:grid}.home-directory-group>nav>a{border-top:1px solid var(--line);grid-template-columns:minmax(0,1fr) auto;gap:.25rem .75rem;padding:1rem 0;display:grid}.home-directory-group>nav strong{font-size:1rem}.home-directory-group>nav span{color:var(--muted);grid-column:1;font-size:.875rem;line-height:1.8}.home-directory-group>nav b{grid-area:1/2/3;align-self:center}.home-directory-group[open] summary{background:#edf4fa;margin-bottom:1rem}.article-hero,.guide-article-hero{padding-top:2rem;padding-bottom:1.25rem}.article-hero .eyebrow,.guide-article-hero .eyebrow{margin-bottom:.5rem}.article-hero h1,.guide-article-hero h1{text-wrap:pretty;font-size:clamp(1.65rem,3vw,2.35rem);line-height:1.65}.article-lead,.guide-article-lead{margin-top:1rem;font-size:1.0625rem;line-height:1.9}.article-author{gap:.75rem;margin-top:1.25rem;padding-top:1rem}.article-author p:first-child{flex-flow:wrap;gap:.25rem 1rem}.reading-meta{margin-top:.5rem}.reading-meta summary{color:var(--green);cursor:pointer;font-size:.875rem}.reading-meta p{margin-top:.5rem}.reading-overview{max-width:900px;margin:0 auto 1.5rem;padding:0 2rem;scroll-margin-top:8rem}.reading-key-points{border-left:4px solid var(--green);background:#edf4fa;padding:1.25rem 1.5rem}.reading-key-points h2,.reading-contents h2{margin:0;font-family:inherit;font-size:1.125rem;font-weight:700;line-height:1.6}.reading-key-points ul{margin:.6rem 0 0;padding:0;list-style:none}.reading-key-points li{align-items:baseline;gap:.75rem;padding:.35rem 0;display:flex}.reading-key-points li>span{color:var(--green);flex:0 0 1.5rem;font-size:.875rem;font-weight:700}.reading-key-points p{margin:0;font-size:1rem;line-height:1.85}.reading-contents{border:1px solid var(--line);background:#fff;padding:1.25rem 1.5rem;display:block}.reading-contents-heading{flex-wrap:wrap;align-items:baseline;gap:.25rem 1rem;display:flex}.reading-contents-heading>span{color:var(--muted);font-size:.875rem}.reading-contents ol{grid-template-columns:repeat(2,minmax(0,1fr));gap:0 1.25rem;margin:.75rem 0 0;padding:0;list-style:none;display:grid}.reading-contents li{border-top:1px solid var(--line);min-width:0}.reading-contents li a{color:var(--ink);align-items:baseline;gap:.65rem;padding:.7rem 0;font-size:1rem;line-height:1.7;display:flex}.reading-contents li a>span:first-child{color:var(--green);flex-shrink:0;font-size:.875rem;font-weight:700}.reading-contents a:hover{color:var(--green);text-underline-offset:.2em;text-decoration:underline}.reading-contents .reading-reference-link{color:var(--green);text-underline-offset:.2em;padding-top:.6rem;font-size:.875rem;text-decoration:underline;display:inline-block}.article-body>.reading-section,.guide-article-body>.reading-section{padding:2rem 0;scroll-margin-top:8rem}.reading-section>h2{align-items:baseline;gap:.8rem;margin-bottom:1rem;font-family:inherit;font-size:clamp(1.25rem,2.2vw,1.625rem);font-weight:700;line-height:1.7;display:flex}.reading-section-number{color:var(--green);border-bottom:2px solid var(--accent);flex-shrink:0;font-size:1rem;display:inline-block}.reading-section>h2>span:last-child{min-width:0}.back-to-contents{width:fit-content;color:var(--green);text-underline-offset:.2em;margin-top:1.5rem;padding:.25rem 0;font-size:.875rem;text-decoration:underline;display:block}.reading-evidence{border:1px solid var(--line);margin:1.5rem 0;scroll-margin-top:8rem;padding:0!important}.reading-evidence>summary,.guide-terms-disclosure>summary{cursor:pointer;padding:1rem 1.25rem;font-size:1rem;font-weight:700}.reading-evidence>div{padding:0 1.25rem 1.25rem;font-size:1rem}.guide-terms-disclosure{border:1px solid var(--line);margin-bottom:1.5rem}.guide-terms-disclosure .page-terms{margin:0}.reading-other-pages{max-width:1080px;margin:0 auto 2rem;padding:0 2rem}.reading-other-pages>summary{cursor:pointer;padding:1rem 0;font-size:1rem;font-weight:700}.reading-other-pages .field-path-navigation{margin:0;padding:1.25rem}.reading-overview a:focus-visible,.back-to-contents:focus-visible,summary:focus-visible{outline-offset:3px;outline:3px solid #165a93}.global-page-controls .contents-control{display:none!important}body:has(#page-overview) .global-page-controls .contents-control{display:flex!important}.page-end-related{grid-template-columns:repeat(auto-fit,minmax(min(100%,220px),1fr))}.page-end-related>a{min-height:0}.page-end-related strong{margin-top:.6rem;font-family:inherit;font-size:1.125rem}.page-end-related p,.article-term-primer dd,.page-terms dd{font-size:1rem}.article-term-primer dt a span,.page-terms dt a span,.editorial-policy-inline{font-size:.875rem}@media (width<=760px){.home-welcome{grid-template-columns:1fr;gap:1.5rem;padding:1.75rem 20px}.home-welcome h1{font-size:clamp(1.5rem,6vw,2rem)}.home-welcome h1>span{max-width:100%;display:block}.home-start-actions{grid-template-columns:1fr;display:grid}#all-pages,#site-purpose,#site-search{scroll-margin-top:11rem}.home-purpose{padding:2rem 20px}.home-purpose-cards{grid-template-columns:1fr;gap:.75rem}.home-purpose-cards article{padding:1rem 1.25rem}.home-purpose-cards h3{margin-top:.15rem}.home-directory-grid{grid-template-columns:1fr}.directory-task-hero.home-search-section{grid-template-columns:1fr;gap:1rem;padding:1.5rem 20px}.reading-overview{padding:0 20px}.reading-key-points,.reading-contents{padding:1rem}.reading-contents ol{grid-template-columns:1fr}.reading-section>h2{text-wrap:pretty;gap:.65rem;font-size:1.3rem}.reading-section-number{font-size:.875rem}.article-hero,.guide-article-hero{padding:1.5rem 20px 1.25rem}.article-author{display:block}.article-author p:first-child{gap:.25rem}.article-author p:first-child>span{flex-basis:100%;display:block}.reading-other-pages{padding:0 20px}:is(.reading-overview,.reading-section,.reading-evidence,.home-directory-group,.home-purpose,#site-search){scroll-margin-top:11rem!important}}#page-overview,.verified-year-heading h2,.editorial-policy-body>section[id]{scroll-margin-top:11rem}@media (width<=700px){body:has(#page-overview) .global-page-controls{grid-template-columns:1.7fr .7fr 1fr}body:has(#page-overview) .global-page-controls a{flex-direction:column;gap:3px;padding:8px 3px}body:has(#page-overview) .global-page-controls span{display:none}.global-page-controls strong{white-space:normal;text-align:center;font-size:.875rem}}@media print{.global-page-controls,.back-to-contents{display:none!important}details>:not(summary){display:block!important}.home-directory-grid,.home-purpose-cards,.home-welcome{display:block}}.home-endoscopy{border-bottom:1px solid var(--line);background:#fff;grid-template-columns:.95fr 1.05fr;gap:2rem;padding:2.5rem max(24px,50vw - 540px);display:grid}.home-endoscopy h2{font-family:var(--font-ui);margin:.5rem 0 1rem;font-size:clamp(1.5rem,2.7vw,2rem);line-height:1.6}.home-endoscopy h2 span{display:inline-block}.home-endoscopy-intro>p:not(.eyebrow){font-size:1rem;line-height:1.95}.endoscopy-purpose-links{grid-template-columns:repeat(2,minmax(0,1fr));align-content:center;gap:.75rem;display:grid}.endoscopy-purpose-links a{border:1px solid var(--line);border-top:3px solid var(--green);color:var(--ink-2);background:#f5f8fc;flex-direction:column;gap:.6rem;min-width:0;padding:1.15rem;text-decoration:none;display:flex}.endoscopy-purpose-links a:hover{border-color:var(--green);background:#edf4fa}.endoscopy-purpose-links a:focus-visible{outline-offset:3px;outline:3px solid #165a93}.endoscopy-purpose-links span{color:var(--green);font-size:.875rem;font-weight:700;line-height:1.6}.endoscopy-purpose-links strong{font-size:1.125rem;line-height:1.6}.endoscopy-purpose-links small{font-size:1rem;line-height:1.8}.endoscopy-detail{border:1px solid var(--line);background:#f5f8fc;margin:1.25rem 0;padding:1rem 1.25rem}.endoscopy-detail summary{cursor:pointer;font-size:1rem;font-weight:700;line-height:1.8}.endoscopy-detail summary:focus-visible{outline-offset:3px;outline:3px solid #165a93}.endoscopy-role-list{padding-left:1.4rem}.endoscopy-role-list li{margin:.75rem 0;font-size:1rem;line-height:1.9}.guide-article-body .treatment-grid article>span{letter-spacing:.02em;font-size:.875rem}.guide-article-body .treatment-grid article>a{margin-top:.9rem;font-size:1rem;line-height:1.7;display:inline-block}.endoscopy-source{font-size:.875rem}#endoscopy,#ercp,#ductoscopy,#interventional-eus,#endoscopy-diagnosis,#less-invasive-care{scroll-margin-top:11rem}@media (width<=900px){.home-endoscopy{grid-template-columns:1fr;gap:1rem}}@media (width<=600px){.home-endoscopy{padding:2rem 20px}.endoscopy-purpose-links{grid-template-columns:1fr}.endoscopy-purpose-links a{gap:.3rem}}@media print{.home-endoscopy,.endoscopy-purpose-links{display:block}}b,strong{font-weight:700}button,input,select,textarea{font-family:var(--font-ui)}[class] :is(h1,h2,h3,h4),.profile-summary>strong,.directory-purpose-section .directory-purpose-main h2{font-weight:700}.eyebrow{font-family:var(--font-ui);letter-spacing:.08em;font-size:.875rem}.site-header{border-top:4px solid var(--ink);border-bottom:1px solid var(--line);-webkit-backdrop-filter:none;backdrop-filter:none;background:#fff}.brand-mark,.guide-brand-mark{background:var(--ink);font-family:var(--font-ui);border-radius:4px;transform:none}.unified-site-header .nav-sitemap,.nav-author,.site-orientation nav a,.home-quick-menu a,.global-page-controls a,.profile-section-nav a{border-radius:4px}.site-orientation{background:var(--surface-soft)}.home-welcome{background:var(--surface-blue);border-bottom:1px solid var(--line)}.home-question-guide{border:1px solid var(--line);border-top:4px solid var(--blue)}.home-quick-menu{background:#fff}.home-quick-menu a{border-color:var(--line);border-top:3px solid var(--blue);color:var(--ink);font-weight:700}.home-quick-menu .home-quick-urgent{color:#943e30;border-color:#b96860}.home-quick-menu .home-quick-urgent:hover{color:#fff;background:#943e30}.home-quick-menu a:hover{color:#fff}.home-directory-group{border-color:var(--line);border-top:3px solid var(--blue)}.home-purpose-cards article{border:1px solid var(--line);border-top:3px solid var(--blue)}.reading-key-points{border:1px solid var(--line);border-left:4px solid var(--blue)}.reading-contents{border-top:0}.reading-section>h2{border-bottom:2px solid var(--line);padding-bottom:.75rem}.reading-section-number{background:var(--surface-blue);color:var(--blue);border:0;border-radius:2px;padding:.1rem .45rem;font-weight:700}.reading-contents li a,.reading-evidence>summary,.endoscopy-detail summary{font-weight:700}.reading-evidence>summary,.guide-terms-disclosure>summary{background:var(--surface-soft)}.home-endoscopy .endoscopy-purpose-links a{background:#fff}.home-endoscopy .endoscopy-purpose-links a:hover{background:var(--surface-blue)}.button-primary,.button-secondary,.button-quiet,.guide-principle-card,.directory-purpose-scope,.directory-search-panel,.global-page-controls a{box-shadow:none}.home-purpose-link,.back-to-contents,.inline-evidence-link a{text-underline-offset:.25em;text-decoration-thickness:1px}.risk-section,.works-section,.audience-card.featured,.guide-journey-section,.two-risk-article article{--accent:var(--accent-on-dark)}.field-path-navigation .is-current small{color:#fff}.site-footer-note{color:#cbd8e6}@media (width<=760px){.home-welcome h1{font-size:clamp(1.5rem,6vw,1.875rem);line-height:1.65}.home-question-guide{padding:1.25rem}.reading-section>h2{gap:.65rem}}.home-return-link.home-return-link{border:1px solid var(--blue);background:var(--blue);color:#fff;border-radius:4px;justify-content:center;align-items:center;gap:.5rem;min-height:48px;padding:.65rem 1rem;font-size:1rem;line-height:1.5;text-decoration:none;display:inline-flex}.home-return-link strong{font-size:inherit;word-break:keep-all}.home-return-icon{flex:0 0 1.25rem;width:1.25rem;height:1.25rem}.home-return-link.home-return-link:hover{background:var(--ink);color:#fff}.home-return-link:focus-visible,.global-page-controls a:focus-visible{outline-offset:3px;outline:3px solid #2879c1}.site-orientation nav{flex-wrap:wrap}.site-orientation nav .home-return-link{font-size:.875rem}.site-orientation nav>a:not(.home-return-link){align-items:center;min-height:44px}.page-end-homes .home-return-link{width:100%}.site-footer-intro .home-return-link{border-color:#b5d8f5}.global-page-controls .home-return-link,.global-page-controls strong{font-size:.875rem}.page-author-credit{border-top:1px solid var(--line);max-width:1080px;color:var(--muted);background:#fff;margin:2rem auto 0;padding:1.5rem 32px 2rem;scroll-margin-top:10rem}.page-author-credit h2{color:var(--ink-2);margin:0 0 .75rem;font-size:1rem;line-height:1.6}.page-author-credit p{margin:.35rem 0;font-size:.875rem;line-height:1.8}.page-author-credit .page-author-identity{flex-wrap:wrap;align-items:baseline;gap:.25rem 1rem;display:flex}.page-author-identity a{font-size:1rem}.page-author-credit nav{flex-wrap:wrap;gap:.25rem 1.25rem;margin-top:.65rem;display:flex}.page-author-credit nav a{align-items:center;min-height:44px;font-size:.875rem;display:inline-flex}.page-author-credit a{color:var(--blue);text-underline-offset:.2em;text-decoration:underline}.page-author-credit a:focus-visible{outline-offset:3px;outline:3px solid #2879c1}@media (width>=901px){.home-directory-grid{grid-template-columns:repeat(3,minmax(0,1fr))}.home-quick-menu>div{grid-template-columns:repeat(5,minmax(0,1fr))}}@media (width<=700px){.page-author-credit{padding:1.25rem 20px 1.5rem}.site-orientation nav .home-return-link{flex:100%}.site-orientation nav>a:not(.home-return-link){font-size:.875rem}.global-page-controls .home-return-link{padding:.5rem .25rem}.global-page-controls .home-return-icon{display:none}.global-page-controls strong{word-break:keep-all;line-height:1.5}}